AUTHOR=Liang Zhi , Song Xiaobiao , Hu Jiang , Wu Riga , Li Pengda , Dong Zhenyu , Liang Lu , Wang Jijun 

TITLE=Fermented Dairy Food Intake and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.812679

DOI=10.3389/fonc.2022.812679

ISSN=2234-943X

ABSTRACT=It was highly controversial whether fermented dairy foods protects against colorectal cancer (CRC) because of conflicting results from current human epidemiologic studies，we therefore conducted this meta-analysis based on the case-control and cohort studies to estimate the holistic analyses. Finally, total of 7 case-control studies and 10 cohort studies comprising a total of >20,000 cases were incorporated in the quantitative synthesis. Specifically, statistical evidence of significantly decreasing CRC risk in case-control studies was found to be associated with Cheese intake (OR = 0.89, 95% CI = 0.82–0.97), In subgroup analysis, Cheese intake were correlated to lower colon cancer (OR = 0.89, 95% CI = 0.79–1.00) and rectal cancer (OR = 0.86, 95% CI = 0.74–1.00) risk in case-control studies. Furthermore, we also found that the higher intake of yogurt may lower the risk of rectal cancer (OR = 0.75, 95% CI = 0.65–0.88) in cohort studies. The consumption of fermented dairy foods may be relevant to decrease CRC risk in this meta-analysis .