AUTHOR=Meng Chunliu , Wang Fang , Chen Minghong , Shi Hongyun , Zhao Lujun , Wang Ping 

TITLE=Construction and Verification of Nomogram Model for Lung Adenocarcinoma With ≤ 5 Bone-Only Metastases Basing on Hematology Markers

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.858634

DOI=10.3389/fonc.2022.858634

ISSN=2234-943X

ABSTRACT=Objectives: This retrospective study investigated prognostic factors in advanced lung adenocarcinoma (LUAD)  with 1-5 bone-only metastasis (BOM), and developed a nomogram model to estimate patient survival.
Methods: We investigated patients with advanced LUAD with 1-5 bone-only metastasis at the initial diagnosis and diagnosed between 2013 and 2019 in two hospitals. A formula named Risk-H was constructed using hematological-variables screened by LASSO-Cox regression analysis in the internal set and verified by the external set. Two nomogram models were developed by clinical variables selected by LASSO-Cox regression analysis with or without Risk-H in the internal set. The concordance index (C-index), calibration curves, time-dependent receiver operating characteristic (ROC) analysis, area under the curve (AUC), and decision curve analysis (DCA) were formulated to verify nomogram models. The primary endpoint was overall survival.
Results: We finally included 125, 69 patients, respectively, in the internal and external sets for analysis. The following were significant hematology prognostic factors, and were included in the Risk-H formula: alkaline phosphatase, albumin, leukocyte. Four clinical factors, including loss of weight, sensitive mutation status, T and N stage, with or without Risk-H were used to establish nomogram models. And C-index, calibration curves, ROC analysis, AUC and DCA showed the addition of hematological data improved the predictive accuracy of survival.
Conclusions: Pretreatment peripheral blood indexes may be a meaningful serum biomarker for prognosis in LUAD. The addition of Risk-H to the nomogram model could serve as a more economical, powerful, and practical method to predict survival for LUAD patients with 1 to 5 BOM.