AUTHOR=Ge Weiyu , Ma Jingyu , Mao Tiebo , Xu Haiyan , Zhang Xiaofei , Li Shumin , Wang Yongchao , Yao Jiayu , Yue Ming , Jiao Feng , Wang Yu , Zhuo Meng , Han Ting , Hu Jiong , Zhang Xiao , Cui Jiujie , Wang Liwei 

TITLE=Distinguishable Prognostic Signatures and Tumor Immunogenicity Between Pancreatic Head Cancer and Pancreatic Body/Tail Cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.890715

DOI=10.3389/fonc.2022.890715

ISSN=2234-943X

ABSTRACT=Background: Pancreatic head cancer and pancreatic body/tail cancer are considered to have different clinical presentation and have altered outcomes. 
Methods: 90 PAAD cases from our institution were used as a discovery set and 166 PAAD cases from TCGA cohort were used as a validation set. According to the anatomic location, the PAAD cases were divided into pancreatic head cancer and pancreatic body/tail cancer two groups. Firstly, different biology function of two groups was assessed by ssGSEA. Meanwhile, ESITMATE and CIBERSORT were conducted to estimate immune infiltration. Then, a novel anatomic site-related risk score (SRS) model was constructed by LASSO and Cox regression. Survival and time-dependent ROC analysis was used to prove the predictive ability of our model in two cohorts. Subsequently, an integrated survival decision tree and a scoring nomogram were constructed to improve prognostic stratification and predictive accuracy for individual patients. In addition, gseaGO and gseaKEGG pathway analysis were performed on genes in the key module by R package. 
Results: Overall survival and the objective response rate (ORR) of patients with pancreatic body/tail cancer was markedly superior to those with pancreatic head cancer. In addition, distinct immune characteristics and gene patterns were observed between two groups. Then, we screened 5 biomarkers related to the prognosis of pancreatic cancer and constructed a more powerful novel SRS model to predict prognosis.
Conclusions: Our research shed some light on the revelation of gene patterns, the immune and mutational landscape characterizations, and their relationships in different PAAD locations.