AUTHOR=Wang Qi , Wang Huizhi , Ding Yuntao , Wan Mengtian , Xu Min 

TITLE=The Role of Adipokines in Pancreatic Cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.926230

DOI=10.3389/fonc.2022.926230

ISSN=2234-943X

ABSTRACT=In modern society, inappropriate diets and other lifestyle habits have made obesity, a chronic epidemic that affects more than half of the world, an increasingly prominent health problem. Adipokines is coming into notice on account of the role of intermediate regulatory junctions between obesity and malignancy. Accordingly, this review summarises the current evidence for the relation between highly concerned adipokines and the pathogenesis of pancreatic cancer (PC). Not only classical adipokines such as leptin and adiponectin are included, but also cover the recently recognized chemerin and osteopontin. Through a summary of the biological functions of these adipokines as well as their receptors, it was discovered that in addition to their basic function of stimulating the biological activity of tumour, more studies confirm that adipokines intervene in the progression of PC from the viewpoint of tumour metabolism, immune escape and reprogramming of the TME. Besides endocrine function, the impact of white adipose tissue (WAT)-induced chronic inflammation on PC is briefly discussed. Furthermore, the potential implication of the newly acknowledged endocrine behavior of brown adipose tissue (BAT) in relation to carcinogenesis is also explored. No matter the broad spectrum of obesity and the poor prognosis of PC, supplemental research is called for to unravel the detailed network of adipokines associated with PC. Exploiting profound therapeutic strategies that target adipokines and their receptors may go some way to improving the current worrying prognosis of PC patients.