AUTHOR=Wolf Isis , Gratzke Christian , Wolf Philipp 

TITLE=Prostate Cancer Stem Cells: Clinical Aspects and Targeted Therapies

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.935715

DOI=10.3389/fonc.2022.935715

ISSN=2234-943X

ABSTRACT=Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis and therapeutic resistance of PC. In this minireview we introduce the PCSC hypothesis and discuss the impact of PCSCs in the clinical practice. Moreover, new therapeutic approaches to combat PCSCs are presented to combat PCSCs for a future with the aim to achieve an improved therapeutic outcome for patients with PC.