AUTHOR=Kaprin Andrey , Pikin Oleg , Ryabov Andrey , Aleksandrov Oleg , Toneev Evgeniy , Lubchenko Ludmila , Zelenova Ekaterina 

TITLE=Case Report: A rare case of familial lung cancer requiring pneumonectomy in three male siblings

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.947210

DOI=10.3389/fonc.2022.947210

ISSN=2234-943X

ABSTRACT=Lung cancer is a disease with a unique genetic pattern and is occasionally related to hereditary syndromes such as Lynch, Louis-Bar, Li-Fraumeni syndrome. In some patients, germinal mutations may be discovered in combination with somatic alterations. For instance, Li-Fraumeni syndrome often reveals a mixture of TP53 and EGFR mutations. The development of new target therapies necessitates an extensive search for new pathogenic mutations.
In this article, we present a rare case report of lung cancer, requiring a pneumonectomy, in three sibling brothers.