AUTHOR=Shentu Weihui , Zhang Yin , Gu Jiaojiao , Wang Fa , Zhao Wei , Liu Chunmei , Lin Zimei , Wang Yao , Liu Chen , Chen Yunyu , Fan Qiyun , Wang Hongying 

TITLE=Contrast-enhanced ultrasonography for differential diagnosis of adnexal masses

JOURNAL=Frontiers in Oncology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.968759

DOI=10.3389/fonc.2022.968759

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Quantitative contrast-enhanced ultrasonography parameters are affected by various factors. We evaluated corrected quantitative contrast enhanced ultrasonography in differentiating benign adnexal tumors from malignant tumors.</p></sec><sec><title>Methods</title><p>Patients with adnexal masses who underwent conventional and contrast-enhanced ultrasonography were included. Contrast-enhanced ultrasonography parameters such as base intensity, arrival time, peak intensity, time to peak intensity, ascending slope, and descending slope were measured. Corrected (time to peak intensity − arrival time) <sub>mass/</sub>(time to peak intensity − arrival time) <sub>uterus</sub> and (peak intensity − base intensity) <sub>mass/</sub>(peak intensity − base intensity) <sub>uterus</sub> were calculated. Lesions were confirmed by pathologic examination of surgical specimens.</p></sec><sec><title>Results</title><p>This study included 31 patients with 35 adnexal lesions including 20 (57.10%) benign and 15 (42.90%) malignant lesions. The corrected contrast-enhanced ultrasonography quantitative parameters in lesions were statistically different between malignant and benign groups (<italic>P</italic>&lt;0.05). The optimal cut-off value for (time to peak intensity − arrival time) <sub>mass</sub>/(time to peak intensity − arrival time) <sub>uterus</sub>, ascending slope, and (peak intensity − base intensity) <sub>mass</sub>/(peak intensity − base intensity) <sub>uterus</sub>, and descending slope for differentiating malignant adnexal masses from benign tumors were 1.05 (area under curve: 0.93,<italic> P</italic>&lt;0.05), 1.11 (area under curve: 0.83, <italic>P</italic>&lt;0.05), 0.82 (area under curve: 0.73, <italic>P</italic>&lt;0.05), and −0.27 (area under curve: 0.66, <italic>P</italic>=0.16), with sensitivity and specificity of 93.33% and 85.00%, 86.67% and 75.00%, 86.67% and 60.00%, and 54.55% and 66.67%, respectively.</p></sec><sec><title>Conclusions</title><p>Corrected contrast-enhanced ultrasonography parameters provide practical differential diagnosis value of adnexal lesions with high reliability for sonologists.</p></sec>