AUTHOR=Shentu Weihui , Zhang Yin , Gu Jiaojiao , Wang Fa , Zhao Wei , Liu Chunmei , Lin Zimei , Wang Yao , Liu Chen , Chen Yunyu , Fan Qiyun , Wang Hongying 

TITLE=Contrast-enhanced ultrasonography for differential diagnosis of adnexal masses

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.968759

DOI=10.3389/fonc.2022.968759

ISSN=2234-943X

ABSTRACT=Background: Quantitative contrast-enhanced ultrasonography parameters are affected by various factors. We evaluated corrected quantitative contrast enhanced ultrasonography in differentiating benign adnexal tumors from malignant tumors.
Methods: Patients with adnexal masses who underwent conventional and contrast-enhanced ultrasonography were included. Contrast-enhanced ultrasonography parameters such as base intensity, arrival time, peak intensity, time to peak intensity, ascending slope, and descending slope were measured. Corrected (time to peak intensity − arrival time) mass / (time to peak intensity − arrival time) uterus and (peak intensity − base intensity) mass / (peak intensity − base intensity) uterus were calculated. Lesions were confirmed by pathologic examination of surgical specimens. 
Results: This study included 31 patients with 35 adnexal lesions including 20 (57.10%) benign and 15 (42.90%) malignant lesions. The corrected contrast-enhanced ultrasonography quantitative parameters in lesions were statistically different between malignant and benign groups (P<0.05). The optimal cut-off value for (time to peak intensity − arrival time) mass / ( time to peak intensity − arrival time) uterus, ascending slope, and (peak intensity − base intensity) mass/( peak intensity − base intensity) uterus, and descending slope for differentiating malignant adnexal masses from benign tumors were 1.05 (area under curve: 0.93, P<0.05), 1.11 (area under curve: 0.83, P<0.05), 0.82 (area under curve: 0.73, P<0.05), and −0.27 (area under curve: 0.66, P=0.16), with sensitivity and specificity of 93.33% and 85.00%, 86.67% and 75.00%, 86.67% and 60.00%, and 54.55% and 66.67%, respectively.
Conclusions: Corrected contrast-enhanced ultrasonography parameters provide practical differential diagnosis value of adnexal lesions with high reliability for radiologists.