AUTHOR=Tan Li , Li Qing-Shu , Peng Dong , Cheng Yong 

TITLE=Does PD-1 blockade play a decisive role in the pathological complete remission of unresectable MSS, BRAF V600E-mutated metastatic colorectal cancer: A case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.976622

DOI=10.3389/fonc.2022.976622

ISSN=2234-943X

ABSTRACT=Background
Colorectal cancer (CRC) ranks the third highest incidence among human cancers. With the continuous development of anti-cancer drugs, CRC patients are treated more and more effectively. However, the treatment of patients with unresectable mCRC remains a core point for surgeons worldwide, especially for those with microsatellite stability (MSS) and BRAF V600E mutation, who has been reported to have the worst prognosis.
Case Description
We report a case of pathological complete remission (PCR) in a patient with unresectable MSS, BRAF V600E-mutated metastatic rectal cancer after using Vemurafenib, Cetuximab in combination with Camrelizumab.
Conclusions
This case suggested that Vemurafenib, Cetuximab combined with Camrelizumab was effective to MSS, BRAF V600E-mutated mCRC. To benefit more patients, further studies need to be completed.