AUTHOR=Li Xiaoliang , Hu Lanyue , Tan Chengning , Wang Xiaojie , Ran Qian , Chen Li , Li Zhongjun 

TITLE=Platelet-promoting drug delivery efficiency for inhibition of tumor growth, metastasis, and recurrence

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.983874

DOI=10.3389/fonc.2022.983874

ISSN=2234-943X

ABSTRACT=Nanomedicines are considered as a strategy for anticancer therapy, however, the low targeting efficiency in vivo is a great obstacle for their clinical application. Camouflaging nanomedicines with platelet membrane (PM) or platelet would significantly prolong the retention time in bloodstream, enhance the targeting ability to tumor cells and reduce the off-target on the major orangs due to the natural properties of platelet in the vivo application. In the current review, the advances of PM or platelet as smart carriers to deliver nanomedicines for the inhibition of tumor growth, metastasis and recurrence were summarized. And the opportunities and challenges of this camouflaging strategy for anticancer treatment were also discussed