AUTHOR=Zhang Tongyi , Wang Hongwei , Cai Zhiwei , Zhang Siqi , Jiang Chongyi 

TITLE=RET rearrangement-positive pancreatic cancer has remarkable response to pralsetinib: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1078076

DOI=10.3389/fonc.2023.1078076

ISSN=2234-943X

ABSTRACT=Because existing treatment options are ineffective, patients with metastatic pancreatic cancer often have a dismal prognosis. RET fusion occurred in just 0.6% of pancreatic cancer. The effectiveness of RET targeted treatment in the fusion of TRIM33-RET alone has not been reported in pancreatic cancer.  Here we present a 68-year-old man with pancreatic cancer harboring TRIM33-RET fusion who responded remarkably to pralsetinib despite being intolerant to chemotherapy. To our knowledge, this is the first report on the clinical value of TRIM33-RET fusion in pancreatic cancer, which may benefit from the targeted therapy.