AUTHOR=Wang Jinghan , Li Linjie , Yu Fang , Zhang Junyu , Mao Liping , Chen Bocheng , Hu Xuelian , Zhou Hongmei , Xie Wanzhuo , Tong Hongyan , Jin Jie 

TITLE=Development and validation of platelet-to-albumin ratio as a clinical predictor for diffuse large B-cell lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1138284

DOI=10.3389/fonc.2023.1138284

ISSN=2234-943X

ABSTRACT=Diffuse large B-cell lymphoma (DLBCL) is the most common subtypes of lymphoma. Clinical biomarkers are still required for DLBCL patients to identify high-risk patients. We developed and validated the platelet-to-albumin (PTA) ratio as a predictor for DLBCL patients. A group of 749 patients was randomly divided into a training set (600 patients) and an internal validation set (149 cases). The independent cohort of 104 110 patients was enrolled from the other hospital as an external validation set. As a result, a U-shaped relation between the PTA ratio and PFS was identified in the training set. The PTA ratio less than 2.7 or greater than 8.6 was associated with the shorter PFS. Additionally, the PTA ratio had an additional prognostic value to the well-established predictors. What’s more, the U-shaped pattern of the PTA ratio and PFS was respectively validated in the two validation sets. In conclusion, a U-shaped association between the PTA ratio and PFS was found in patients with DLBCLs. The PTA ratio can be used as a robust biomarker to identify high-risk patients in clinical practice. , and may suggest abnormalities of both host nutritional aspect and systemic inflammation in DLBCL.