AUTHOR=Peng Lei , Xu Quan , Yin Sui , Zhang Ye , Wu Hao , Liu Yangchun , Chen Liru , Hu Yeji , Yuan Jun , Peng Kai , Lin Qin 

TITLE=The emerging nanomedicine-based technology for non-small cell lung cancer immunotherapy: how far are we from an effective treatment

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1153319

DOI=10.3389/fonc.2023.1153319

ISSN=2234-943X

ABSTRACT=The non-small cell lung cancer (NSCLC) keeps the leading common cause of cancer-associated mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances in research aiming to understand its intricate nature. Based on the conventional therapies, we have more chances to get the nanotechnology that can be considered to improve the clinical outcomes of NSCLC patients. Actually, the development of new emerging immunotherapies based on the recently understood interaction of the immune system with the tumor highlights some potential for treating NSCLC from the early stages. We believe with the new engineering avenues with nanomedicine, we will able to overcome the intrinsic limits of conventional and emerging therapies regarding off-site cytotoxicity, drug resistance and drug administration issues. The combination of nanotechnology to the convergence points of current therapies can pave the way for obtaining unmet needs for NSCLC treatment currently.