AUTHOR=Li Ningning , Gao Liwei , Ge Yuping , Zhao Lin , Bai Chunmei , Wang Yingyi 

TITLE=Prognostic and predictive significance of circulating biomarkers in patients with advanced upper gastrointestinal cancer undergoing systemic chemotherapy

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1195848

DOI=10.3389/fonc.2023.1195848

ISSN=2234-943X

ABSTRACT=Objective: The prognosis of patients with advanced cancers of the upper gastrointestinal (UGI) tract is poor. This study aimed to investigate the predictive and prognostic values of circulating biomarkers in patients with advanced esophageal and gastric cancers receiving chemotherapy.   
Design: Overall, 92 patients with advanced esophageal squamous cell carcinoma (ESCC; n=38) and gastric adenocarcinoma (GAC; n=54) were enrolled. We analyzed the association of circulating lymphocyte subsets,  blood biomarkers with treatment efficacy and patient survival. 
Results: Hemoglobin (Hb, p=0.014), eosinophil (p=0.028), CD4+CD28+T/CD4+T percentage (p=0.049), CD8+CD38+T/CD8+T percentage (p=0.044), memory CD4+T (p=0.007) and CD4+CD28+T (p=0.007) were determined as predictors for achieving non-PD (progression disease) in the ESCC cohort. High levels of eosinophils (p=0.030) and memory CD4+T cells (p=0.026) and high eosinophil-to-lymphocyte ratio (ELR, p=0.013) were predictors of non-PD in patients with GAC. The combined detection models exhibited good ability to distinguish between partial response (PR)/non-PR and PD/non-PD in patients with ESCC and GAC, respectively. Using the multivariate Cox model, the Eastern Cooperative Oncology Group score (ECOG) status (hazard ratio [HR]: 4.818, 95% confidence intervals [CI]: 2.076–11.184, p<0.001) and eosinophil count (HR: 0.276, 95% CI: 0.120–0.636, p=0.003) were independent prognostic factors of progression-free survival (PFS) in patients with ESCC. Metastatic sites (HR: 2.092, 95% CI: 1.307–3.351, p=0.002) and eosinophil-to-lymphocyte ratio (ELR; HR: 0.379, 95% CI: 0.161–0.893, p=0.027) were independent prognostic factors for overall survival (OS) in patients with ESCC. Differentiation (HR: 0.041, 95% CI: 0.200–0.803, p=0.010), memory CD4+T (HR: 0.304, 95% CI: 0.137–0.675, p=0.003), NK cells (HR: 2.302, 95% CI: 1.044–3.953, p=0.037), and C-reactive protein-to-lymphocyte ratio (CLR; HR: 2.070, 95% CI: 1.024–4.186, p=0.043) were independent prognostic factors for PFS in patients with GAC. Total lymphocyte counts (HR: 0.260, 95% CI: 0.086–0.783, p=0.017), CD8+T (HR: 0.405, 95% CI: 0.165–0.997, p=0.049), NK cells (HR: 3.395, 95% CI: 1.592–7.238, p=0.002) and monocyte-to-lymphocyte ratio (MLR; HR: 3.076, 95% CI: 1.488–6.360, p=0.002) were identified as independent prognostic factors associated with OS of GAC.
Conclusion: Lymphocyte subsets, blood cell counts, and inflammatory parameters may predict the chemotherapeutic response and prognosis in ESCC and GAC. A combination of these markers can be used to stratify patients into risk groups.