AUTHOR=Becht Rafał , Kiełbowski Kajetan , Żychowska Justyna , Dembowska Wiktoria , Król Małgorzata , Birkenfeld Bożena , Owsiak Mateusz , Lewandowska Magdalena , Kubrak Jadwiga , Amernik Katarzyna 

TITLE=Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1222418

DOI=10.3389/fonc.2023.1222418

ISSN=2234-943X

ABSTRACT=Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient's condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness 2 This is a provisional file, not the final typeset article on the aggressive laryngeal SCC and its good response to first line chemotherapy composed of cisplatin and etoposide, followed by radiotherapy.