AUTHOR=Becht Rafał , Kiełbowski Kajetan , Żychowska Justyna , Dembowska Wiktoria , Król Małgorzata , Birkenfeld Bożena , Owsiak Mateusz , Lewandowska Magdalena , Kubrak Jadwiga , Amernik Katarzyna TITLE=Small cell carcinoma with neuroendocrine differentiation of subglottic larynx- a case report JOURNAL=Frontiers in Oncology VOLUME=Volume 13 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1222418 DOI=10.3389/fonc.2023.1222418 ISSN=2234-943X ABSTRACT=

Small cell cancer (SCC) is a neuroendocrine neoplasm, which is most frequently found in the lungs. Extrapulmonary location of SCC is rare and may involve 2.5-5% of SCCs. We present a case of a 31-year-old male patient with an extremely uncommon subglottic SCC. The patient was qualified for a radical sequential chemoradiotherapy. After treatment, patient’s condition suggested complete remission. Recurrence was detected one year later, and the disease rapidly progressed, despite a second line chemotherapy. The patient died 29 months after initial diagnosis. This case aims to raise awareness on the aggressive laryngeal SCC and its good response to first line chemotherapy composed of cisplatin and etoposide, followed by radiotherapy.