AUTHOR=Gao Xiaofeng , Ding Pingan , Zhang Zhidong , Li Yong , Zhao Qun , Wang Dong , Zhao Xuefeng , Liu Yu , Tan Bibo 

TITLE=Analysis of recurrence and metastasis patterns and prognosis after complete resection of retroperitoneal liposarcoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1273169

DOI=10.3389/fonc.2023.1273169

ISSN=2234-943X

ABSTRACT=Objective: To analyze the recurrence and metastasis patterns and prognosis after complete resecti on of retroperitoneal liposarcoma. Methods: The clinical postoperative follow-up data and results of patients who underwent complete resection of retroperitoneal liposarcoma from September 10, 2014, to September 8, 2021, at Hebei Medical University hospital were collected retrospectively.Results: A total of 60 patients with complete resection of retroperitoneal liposarcoma, including 33 cases of retroperitoneal liposarcoma recurrence, 2 cases of liver metastasis, and 1 case of lun g metastasis, were included. The results showed that 100% of the recurrent sites were located in the primary region of the tumor, with most recurrences located near the kidney, paracolic sulci, and iliac vessels. Three patients had distant metastasis without obvious recurrence on imaging ex amination. The pathological type of retroperitoneal liposarcoma, Ki67 expression, and presence of serum albumin were risk factors for recurrence and metastasis after complete resection of retrop eritoneal liposarcoma. The malignancy and Ki67 expression were independent risk factors for rec urrence and metastasis as well as for overall survival of patients undergoing complete resection of retroperitoneal liposarcoma. Conclusion: Complete resection remains the most effective method to treat retroperitoneal liposarcoma. Patients with pathological types of retroperitoneal liposarcoma showing dedifferentiation, pleomorphism, mixed type, and high Ki67 expression should be closel y monitored and observed after complete resection, especially for imaging changes in the primar y tumor area.