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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Oncol.</journal-id>
<journal-title>Frontiers in Oncology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Oncol.</abbrev-journal-title>
<issn pub-type="epub">2234-943X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fonc.2023.1287253</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Oncology</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Triple-negative and Her2-positive breast cancer in women aged 70 and over: prognostic impact of age according to treatment</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Houvenaeghel</surname>
<given-names>Gilles</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/740584"/>
<role content-type="https://credit.niso.org/contributor-roles/conceptualization/"/>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
<role content-type="https://credit.niso.org/contributor-roles/formal-analysis/"/>
<role content-type="https://credit.niso.org/contributor-roles/investigation/"/>
<role content-type="https://credit.niso.org/contributor-roles/methodology/"/>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/supervision/"/>
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<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cohen</surname>
<given-names>Monique</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gon&#xe7;alves</surname>
<given-names>Anthony</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/978058"/>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Berthelot</surname>
<given-names>Axel</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chauvet</surname>
<given-names>Marie Pierre</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Faure</surname>
<given-names>Christelle</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Classe</surname>
<given-names>Jean Marc</given-names>
</name>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jouve</surname>
<given-names>Eva</given-names>
</name>
<xref ref-type="aff" rid="aff6">
<sup>6</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sabiani</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bannier</surname>
<given-names>Marie</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tassy</surname>
<given-names>Louis</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Martino</surname>
<given-names>Marc</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tallet</surname>
<given-names>Agn&#xe8;s</given-names>
</name>
<xref ref-type="aff" rid="aff7">
<sup>7</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/resources/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>de Nonneville</surname>
<given-names>Alexandre</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1616097"/>
<role content-type="https://credit.niso.org/contributor-roles/conceptualization/"/>
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</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>Department of Surgical Oncology, Cancer Research Center of Marseille (CRCM), Institut Paoli&#x2212;Calmettes, Aix-Marseille Univ, CNRS, INSERM</institution>, <addr-line>Marseille</addr-line>, <country>France</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Medical Oncology, Cancer Research Center of Marseille (CRCM), Institut Paoli&#x2212;Calmettes, Aix-Marseille Univ, CNRS, INSERM</institution>, <addr-line>Marseille</addr-line>, <country>France</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>Surgical Oncology Department, Centre Oscar Lambret</institution>, <addr-line>Lille</addr-line>, <country>France</country>
</aff>
<aff id="aff4">
<sup>4</sup>
<institution>Surgical Oncology Department, Centre L&#xe9;on B&#xe9;rard</institution>, <addr-line>Lyon</addr-line>, <country>France</country>
</aff>
<aff id="aff5">
<sup>5</sup>
<institution>Institut Ren&#xe9; Gauducheau, Site hospitalier Nord</institution>, <addr-line>St Herblain</addr-line>, <country>France</country>
</aff>
<aff id="aff6">
<sup>6</sup>
<institution>Surgical Oncology Department, Centre Claudius Regaud</institution>, <addr-line>Toulouse</addr-line>, <country>France</country>
</aff>
<aff id="aff7">
<sup>7</sup>
<institution>Department of Radiotherapy, Cancer Research Center of Marseille (CRCM), Institut Paoli&#x2212;Calmettes, Aix-Marseille Univ, CNRS, INSERM</institution>, <addr-line>Marseille</addr-line>, <country>France</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Charles Theillet, Institut du Cancer de Montpellier (ICM), France</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Cvetka Gra&#x161;i&#x10d; Kuhar, Institute of Oncology Ljubljana, Slovenia</p>
<p>Toshima Z. Parris, University of Gothenburg, Sweden</p>
</fn>
<fn fn-type="corresp" id="fn001">
<p>*Correspondence: Gilles Houvenaeghel, <email xlink:href="mailto:houvenaeghelg@ipc.unicancer.fr">houvenaeghelg@ipc.unicancer.fr</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>15</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="collection">
<year>2023</year>
</pub-date>
<volume>13</volume>
<elocation-id>1287253</elocation-id>
<history>
<date date-type="received">
<day>01</day>
<month>09</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>30</day>
<month>11</month>
<year>2023</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2023 Houvenaeghel, Cohen, Gon&#xe7;alves, Berthelot, Chauvet, Faure, Classe, Jouve, Sabiani, Bannier, Tassy, Martino, Tallet and de Nonneville</copyright-statement>
<copyright-year>2023</copyright-year>
<copyright-holder>Houvenaeghel, Cohen, Gon&#xe7;alves, Berthelot, Chauvet, Faure, Classe, Jouve, Sabiani, Bannier, Tassy, Martino, Tallet and de Nonneville</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Elderly breast cancer (BC) patients have been underrepresented in clinical trials whereas ~60% of deaths from BC occur in women aged 70 years and older. Only limited data are available on the prognostic impact of age according to treatment, especially in the triple-negative (TN) and Her2-positive because of the lower frequency of these subtypes in elderly patients. We report herein the results of a multicenter retrospective study analyzing the prognostic impact of age according to treatment delivered in TN and Her2-positive BC patients of 70 years or older, including comparison by age groups.</p>
</sec>
<sec>
<title>Methods</title>
<p>The medical records of 31,473 patients treated from January 1991 to December 2018 were retrieved from 13 French cancer centers for retrospective analysis. Our study population included all &#x2265;70 patients with TN or Her2-positive BC treated by upfront surgery. Three age categories were determined: 70-74, 75-80, and &gt; 80 years.</p>
</sec>
<sec>
<title>Results</title>
<p>Of 528 patients included, 243 patients were 70-74 years old (46%), 172 were 75-80 years (32.6%) and 113 were &gt;80 years (21.4%). Half the population (51.9%, 274 patients) were TN, 30.1% (159) Her2-positive/hormone receptors (HR)-positive, and, 18% (95) Her2-positive/endocrine receptors (ER)-negative BC. Advanced tumor stage was associated with older age but no other prognostic factors (tumor subtype, tumor grade, LVI). Adjuvant chemotherapy delivery was inversely proportional to age. With 49 months median follow-up, all patient outcomes (overall survival (OS), disease-free survival (DFS), breast cancer-specific survival (BCSS), and recurrence-free survival (RFS)) significantly decreased as age increased. In multivariate analysis, age &gt;80, pT2-3 sizes, axillary macrometastases, lymphovascular involvement, and HR-negativity tumor negatively affected DFS and OS. Comparison between age &gt;80 and &lt;=80 years old showed worse RFS in patients aged &gt; 80 (HR=1.771, p=0.031).</p>
</sec>
<sec>
<title>Conclusion</title>
<p>TN and Her2-positive subtypes occur at similar frequency in elderly patients. Older age is associated with more advanced tumor stage presentation. Chemotherapy use decreases with older age without worse other pejorative prognostic factors. Age &gt;80, but not &#x2264;80, independently affected DFS and OS.</p>
</sec>
</abstract>
<kwd-group>
<kwd>breast cancer</kwd>
<kwd>triple negative</kwd>
<kwd>HER2-positive</kwd>
<kwd>elderly patients</kwd>
<kwd>geriatric oncology</kwd>
</kwd-group>
<counts>
<fig-count count="2"/>
<table-count count="6"/>
<equation-count count="0"/>
<ref-count count="87"/>
<page-count count="16"/>
<word-count count="6792"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-in-acceptance</meta-name>
<meta-value>Breast Cancer</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Highlights:</title>
<list list-type="bullet">
<list-item>
<p>TN and Her2-positive subtypes occur at a similar frequency in elderly patients</p>
</list-item>
<list-item>
<p>Older age is associated with more advanced tumor stage presentation</p>
</list-item>
<list-item>
<p>Chemotherapy use decreases with older age without worse other pejorative prognostic factors.</p>
</list-item>
<list-item>
<p>Age &gt;80, but not &#x2264;80, independently affected DFS and OS.</p>
</list-item>
</list>
</sec>
<sec id="s2" sec-type="intro">
<title>Introduction</title>
<p>Breast cancer (BC) incidence increases with age and more than one-third of patients with newly diagnosed breast cancer are aged 65 years or older (<xref ref-type="bibr" rid="B1">1</xref>). Although not fully consensual, a patient is considered elderly after the age of 70 according to several international recommendations (<xref ref-type="bibr" rid="B2">2</xref>). Between 1990 and 2023, the annual number of new BC in women doubled in France from 29,934 to 61,214 annual cases (+104%) (<xref ref-type="bibr" rid="B3">3</xref>). Half of this increase is attributable to population growth and aging (+26% and +21%, respectively). Age-specific trends show an average increase in breast cancer of approximately +1% per year for all ages, except for women in their 70s, for whom the increase is greater (+1.9%) (<xref ref-type="bibr" rid="B4">4</xref>). The decrease in breast cancer mortality is the result of major therapeutic advances (hormone therapy, taxanes, and anti-Her2 targeted therapy) associated with an increase in the proportion of cancers diagnosed at an early stage, notably through organized screening. However, this benefit in mortality appears to be less obvious in the elderly patient and 60% of deaths related to breast cancer occur in women aged 65 and over (<xref ref-type="bibr" rid="B4">4</xref>).</p>
<p>Elderly patients present more advanced BC, partly due to the absence of systemic screening (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B6">6</xref>), display higher rates of hormone receptors (HR)-positive/Her2-negative cases than younger cohorts such as those included in pivotal studies (<xref ref-type="bibr" rid="B7">7</xref>), with higher triple-negative (TN) BC and Her2-positive tumors in young (&lt;= 40 years old) and very young (&lt;= 35 years old) patients (<xref ref-type="bibr" rid="B8">8</xref>). Elderly BC patients are often under-treated compared with younger BC patients (<xref ref-type="bibr" rid="B9">9</xref>&#x2013;<xref ref-type="bibr" rid="B12">12</xref>) and present higher rates of recurrence and mortality (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B13">13</xref>&#x2013;<xref ref-type="bibr" rid="B17">17</xref>), with a 5-year survival rate of 82.4% in patients 70-79 and 74% in patients more than 80 (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B17">17</xref>&#x2013;<xref ref-type="bibr" rid="B19">19</xref>). To note that non-compliance to endocrine therapy and radiotherapy is higher in patients 80 years and older (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B20">20</xref>&#x2013;<xref ref-type="bibr" rid="B25">25</xref>). Most elderly patients are considered for upfront surgery, whatever the tumor phenotype and neo-adjuvant treatments seem less frequently offered to older patients, particularly those patients more than 80 years. However, an increasing proportion of elderly women appears as fit with few comorbidities and should be offered similar treatments to younger women. Hence, a significant proportion of older patients with TN and Her2-positive BC should receive neo-adjuvant chemotherapy (+/- Trastuzumab): cN1 or cN0 usN1 with positive axillary lymph node and cN0 pT2. Meanwhile, neo-adjuvant chemotherapy is discussed in patients with cN0 pT1c (mainly in 15-20 mm tumors) (<xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B27">27</xref>). After up-front surgery, lymph node-positive or lymph node-negative and &gt; pT1b patients should receive adjuvant chemotherapy in TN phenotypes (<xref ref-type="bibr" rid="B28">28</xref>, <xref ref-type="bibr" rid="B29">29</xref>) and adjuvant chemotherapy and Trastuzumab in Her2-positive disease (<xref ref-type="bibr" rid="B28">28</xref>, <xref ref-type="bibr" rid="B30">30</xref>).</p>
<p>There is a lack of data on TN and Her2-positive BC in elderly patients because of the lower frequency of these subtypes. We report herein the results of a multicenter retrospective study analyzing the prognostic impact of age according to treatment delivered in TN and Her2-positive BC patients of 70 years or older, including comparison by age groups (70-74, 75-80, and &gt;80 years). Comparison between patients 70-80 years and &gt;80-years, and results according to age groups for pT1, pN0 or pN0(i+) or pN1mi were analyzed.</p>
</sec>
<sec id="s3">
<title>Methods</title>
<sec id="s3_1">
<title>Study design and data source</title>
<p>The medical records of 31,473 patients treated for invasive BC by up-front surgery were retrieved from the clinical databases of 13 cancer centers in France for retrospective analysis. All clinical variables analyzed in this study were retrieved from patient&#x2019;s medical records. Up-front surgery was realized for 14,488 patients from January 1991 to December 2018, including 11,495 (79.3%) HR-positive Her2-negative BC, 1,232 (8.5%) TNBC, and 1,761 (12.1%) Her2-positive BC (614 HR-negative and 1,147 HR-positive). Patients &#x2265;70 represented 19.2% (2,206/11,495), 22.2% (274/1,232), and 14.4% (254/1,761) of HR-positive Her2-negative, TN, and Her2-positive BC, respectively. Our study population included all &#x2265;70 patients with TN or Her2-positive BC treated by upfront surgery (<xref ref-type="supplementary-material" rid="SF1">
<bold>Supplementary Figure&#xa0;1</bold>
</xref>). Three categories of age were determined: 70-74, 75-80, and &gt; 80 years.</p>
<p>Factors associated with adjuvant chemotherapy administration, type of surgery (breast conservative surgery or mastectomy, sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND)), radiation therapy delivery (regional nodal irradiation (RNI), post-mastectomy radiotherapy (PMRT)) were analyzed with univariate and multivariate analyses. Overall survival (OS), disease-free survival (DFS), and breast cancer-specific survival (BCSS) were assessed with univariate and multivariate analyses. In this large cohort of patients, chemotherapy regimens were not recorded. However, during this long period, chemotherapy differ, particularly before and since 2005. Consequently, we analyzed results also according these two periods.</p>
</sec>
<sec id="s3_2">
<title>Pathological assessment</title>
<p>ER and Her2 status were determined according to French guidelines (immunohistochemistry (IHC) detection on formalin-fixed paraffin-embedded samples, of estrogen and/or progesterone receptors with a 10% threshold for ER positivity; Her2 positivity with a 3+ IHC score and/or Her2 amplification identified by <italic>in situ</italic> hybridization). Lymphovascular invasion (LVI), defined as tumor cells lying in an endothelium-lined space within the peritumoral area, were assessed by trained pathologists on examination of hematoxylin, eosin &amp; safran (HES) slides (<xref ref-type="bibr" rid="B31">31</xref>).</p>
</sec>
<sec id="s3_3">
<title>Statistical analysis</title>
<p>Overall survival (1), DFS (2), relapse-free survival (RFS, 3), and BCSS (4) were defined as the time interval from the date of surgery to (1) death or last follow-up, (2) any event (recurrence, metastasis, or death) or last follow-up, (3) local, regional, or distant recurrence whichever comes first or last follow-up, and (4) the date of cancer death or last follow-up, respectively. Patients lost to follow-up were considered alive at the date of last contact. The associations between categorical values were evaluated via &#x3c7;<sup>2</sup> tests. Factors significantly associated with pN status were determined by binary logistic regression adjusted for all significant variables determined by univariate analysis. Survival functions were calculated using the Kaplan-Meier method with differences assessed via the log-rank test. Multivariate survival analyses were performed using the Cox proportional-hazard-regression model adjusted for significant variables. Statistical significance was set at <italic>p &#x2264;</italic> 0.05. Analyses were performed with SPSS-16.0 (SPSS-Inc., Chicago-Illinois, USA) and R version 3.2.4 software (<ext-link ext-link-type="uri" xlink:href="http://www.cran.r-project.org/">http://www.cran.r-project.org/</ext-link>). All procedures performed in this study involving human participants were done by the French ethical standards and with the 2008 Helsinki Declaration. As this was a retrospective non-interventional study, no formal personal consent was required. Authorization to use the database was obtained from the strategic orientation committee of Paoli-Calmettes Institute (ClinicalTrials.gov NCT02869607).</p>
</sec>
</sec>
<sec id="s4" sec-type="results">
<title>Results</title>
<sec id="s4_1">
<title>Patient characteristic</title>
<p>Five hundred twenty-eight patients fulfilled the inclusion criteria, including 243 patients 70-74 years old (46%), 172 75-80 years (32.6%), and 113 &gt; 80 years (21.4%). Half the study population (51.9%, 274 patients) were TN, 30.1% (159) HR-positive and Her2-positive, and 18% (95) HR-negative and Her2-positive BC. The higher the age, the more the tumor stage was advanced (higher tumor size, more node involvement). Other prognostic factors (tumor subtype, tumor grade, LVI) were not significantly different between group ages (<xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>).</p>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Characteristics of patients in the three age groups.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" colspan="2" rowspan="2" align="left">Triple Negative &amp; Her2+</th>
<th valign="top" align="center">Total</th>
<th valign="bottom" align="center"/>
<th valign="bottom" colspan="2" align="center">70-74</th>
<th valign="bottom" colspan="2" align="center">75-80</th>
<th valign="bottom" colspan="2" align="center">&gt; 80</th>
<th valign="top" align="center">Chi 2</th>
</tr>
<tr>
<th valign="bottom" align="center">Nb</th>
<th valign="bottom" align="center">%</th>
<th valign="bottom" align="center">Nb</th>
<th valign="bottom" align="center">%</th>
<th valign="bottom" align="center">Nb</th>
<th valign="bottom" align="center">%</th>
<th valign="bottom" align="center">Nb</th>
<th valign="bottom" align="center">%</th>
<th valign="bottom" align="center">p</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">All patients</td>
<td valign="bottom" align="left"/>
<td valign="bottom" align="center">528</td>
<td valign="bottom" align="center"/>
<td valign="bottom" align="center">243</td>
<td valign="bottom" align="center">46.0</td>
<td valign="bottom" align="center">172</td>
<td valign="bottom" align="center">32.6</td>
<td valign="bottom" align="center">113</td>
<td valign="bottom" align="center">21.4</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">Subtype</td>
<td valign="bottom" align="left">ER- Her2-</td>
<td valign="bottom" align="center">274</td>
<td valign="bottom" align="center">51.9</td>
<td valign="bottom" align="center">131</td>
<td valign="bottom" align="center">53.9</td>
<td valign="bottom" align="center">78</td>
<td valign="bottom" align="center">45.3</td>
<td valign="bottom" align="center">65</td>
<td valign="bottom" align="center">57.5</td>
<td valign="bottom" align="center">0.222</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">ER+ Her2+</td>
<td valign="bottom" align="center">159</td>
<td valign="bottom" align="center">30.1</td>
<td valign="bottom" align="center">72</td>
<td valign="bottom" align="center">29.6</td>
<td valign="bottom" align="center">60</td>
<td valign="bottom" align="center">34.9</td>
<td valign="bottom" align="center">27</td>
<td valign="bottom" align="center">23.9</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">ER- Her2+</td>
<td valign="bottom" align="center">95</td>
<td valign="bottom" align="center">18.0</td>
<td valign="bottom" align="center">40</td>
<td valign="bottom" align="center">16.5</td>
<td valign="bottom" align="center">34</td>
<td valign="bottom" align="center">19.8</td>
<td valign="bottom" align="center">21</td>
<td valign="bottom" align="center">18.6</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">Breast surgery</td>
<td valign="bottom" align="left">Conservative</td>
<td valign="bottom" align="center">321</td>
<td valign="bottom" align="center">60.8</td>
<td valign="bottom" align="center">171</td>
<td valign="bottom" align="center">70.4</td>
<td valign="bottom" align="center">94</td>
<td valign="bottom" align="center">54.7</td>
<td valign="bottom" align="center">56</td>
<td valign="bottom" align="center">49.6</td>
<td valign="bottom" align="center">0.001</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Mastectomy</td>
<td valign="bottom" align="center">190</td>
<td valign="bottom" align="center">36.0</td>
<td valign="bottom" align="center">68</td>
<td valign="bottom" align="center">28.0</td>
<td valign="bottom" align="center">70</td>
<td valign="bottom" align="center">40.7</td>
<td valign="bottom" align="center">52</td>
<td valign="bottom" align="center">46.0</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">Unknown</td>
<td valign="bottom" align="center">&#xa0;</td>
<td valign="bottom" align="center">&#xa0;</td>
<td valign="bottom" align="center">4</td>
<td valign="bottom" align="center">1.6</td>
<td valign="bottom" align="center">8</td>
<td valign="bottom" align="center">4.7</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">4.4</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">ALND</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">289</td>
<td valign="bottom" align="center">54.7</td>
<td valign="bottom" align="center">149</td>
<td valign="bottom" align="center">61.3</td>
<td valign="bottom" align="center">86</td>
<td valign="bottom" align="center">50.0</td>
<td valign="bottom" align="center">54</td>
<td valign="bottom" align="center">47.8</td>
<td valign="bottom" align="center">0.018</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">239</td>
<td valign="bottom" align="center">45.3</td>
<td valign="bottom" align="center">94</td>
<td valign="bottom" align="center">38.7</td>
<td valign="bottom" align="center">86</td>
<td valign="bottom" align="center">50.0</td>
<td valign="bottom" align="center">59</td>
<td valign="bottom" align="center">52.2</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">Radiotherapy</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">91</td>
<td valign="bottom" align="center">17.2</td>
<td valign="bottom" align="center">34</td>
<td valign="bottom" align="center">14.0</td>
<td valign="bottom" align="center">14.5</td>
<td valign="bottom" align="center">32</td>
<td valign="bottom" align="center">28.3</td>
<td valign="bottom" align="center">&#xa0;</td>
<td valign="bottom" align="center">0.010</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">409</td>
<td valign="bottom" align="center">77.5</td>
<td valign="bottom" align="center">196</td>
<td valign="bottom" align="center">80.7</td>
<td valign="bottom" align="center">80.8</td>
<td valign="bottom" align="center">74</td>
<td valign="bottom" align="center">65.5</td>
<td valign="bottom" align="center"/>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">unknown</td>
<td valign="bottom" align="center">28</td>
<td valign="bottom" align="center">5.3</td>
<td valign="bottom" align="center">13</td>
<td valign="bottom" align="center">5.3</td>
<td valign="bottom" align="center">4.7</td>
<td valign="bottom" align="center">7</td>
<td valign="bottom" align="center">6.2</td>
<td valign="bottom" align="center"/>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">RNI</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">174</td>
<td valign="bottom" align="center">48.1</td>
<td valign="bottom" align="center">86</td>
<td valign="bottom" align="center">50.3</td>
<td valign="bottom" align="center">54</td>
<td valign="bottom" align="center">42.9</td>
<td valign="bottom" align="center">34</td>
<td valign="bottom" align="center">52.3</td>
<td valign="bottom" align="center">0.337</td>
</tr>
<tr>
<td valign="bottom" align="left">(n=362 known)</td>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">188</td>
<td valign="bottom" align="center">51.9</td>
<td valign="bottom" align="center">85</td>
<td valign="bottom" align="center">49.7</td>
<td valign="bottom" align="center">72</td>
<td valign="bottom" align="center">57.1</td>
<td valign="bottom" align="center">31</td>
<td valign="bottom" align="center">47.7</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Mastectomy</td>
<td valign="bottom" align="left">No RTH</td>
<td valign="bottom" align="center">67</td>
<td valign="bottom" align="center">35.3</td>
<td valign="bottom" align="center">25</td>
<td valign="bottom" align="center">36.8</td>
<td valign="bottom" align="center">19</td>
<td valign="bottom" align="center">27.1</td>
<td valign="bottom" align="center">23</td>
<td valign="bottom" align="center">44.2</td>
<td valign="bottom" align="center">0.141</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">RTH</td>
<td valign="bottom" align="center">123</td>
<td valign="bottom" align="center">64.7</td>
<td valign="bottom" align="center">43</td>
<td valign="bottom" align="center">63.2</td>
<td valign="bottom" align="center">51</td>
<td valign="bottom" align="center">72.9</td>
<td valign="bottom" align="center">29</td>
<td valign="bottom" align="center">55.8</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">AC</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">246</td>
<td valign="bottom" align="center">46.6</td>
<td valign="bottom" align="center">93</td>
<td valign="bottom" align="center">38.3</td>
<td valign="bottom" align="center">71</td>
<td valign="bottom" align="center">41.3</td>
<td valign="bottom" align="center">82</td>
<td valign="bottom" align="center">72.6</td>
<td valign="bottom" align="center">&lt;0.0001</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">282</td>
<td valign="bottom" align="center">53.4</td>
<td valign="bottom" align="center">150</td>
<td valign="bottom" align="center">61.7</td>
<td valign="bottom" align="center">101</td>
<td valign="bottom" align="center">58.7</td>
<td valign="bottom" align="center">31</td>
<td valign="bottom" align="center">27.4</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Endocrine therapy*</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">12</td>
<td valign="bottom" align="center">7.5</td>
<td valign="bottom" align="center">3</td>
<td valign="bottom" align="center">4.2</td>
<td valign="bottom" align="center">4</td>
<td valign="bottom" align="center">6.7</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">18.5</td>
<td valign="bottom" align="center">0.052</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">147</td>
<td valign="bottom" align="center">92.5</td>
<td valign="bottom" align="center">69</td>
<td valign="bottom" align="center">95.8</td>
<td valign="bottom" align="center">56</td>
<td valign="bottom" align="center">93.3</td>
<td valign="bottom" align="center">22</td>
<td valign="bottom" align="center">81.5</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">cT stage</td>
<td valign="bottom" align="left">T0</td>
<td valign="bottom" align="center">103</td>
<td valign="bottom" align="center">19.5</td>
<td valign="bottom" align="center">65</td>
<td valign="bottom" align="center">26.7</td>
<td valign="bottom" align="center">26</td>
<td valign="bottom" align="center">15.1</td>
<td valign="bottom" align="center">12</td>
<td valign="bottom" align="center">10.6</td>
<td valign="bottom" align="center">&lt;0.0001</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">T1</td>
<td valign="bottom" align="center">195</td>
<td valign="bottom" align="center">36.9</td>
<td valign="bottom" align="center">101</td>
<td valign="bottom" align="center">41.6</td>
<td valign="bottom" align="center">63</td>
<td valign="bottom" align="center">36.6</td>
<td valign="bottom" align="center">31</td>
<td valign="bottom" align="center">27.4</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">T2</td>
<td valign="bottom" align="center">168</td>
<td valign="bottom" align="center">31.8</td>
<td valign="bottom" align="center">56</td>
<td valign="bottom" align="center">23.0</td>
<td valign="bottom" align="center">63</td>
<td valign="bottom" align="center">36.6</td>
<td valign="bottom" align="center">49</td>
<td valign="bottom" align="center">43.4</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">T3</td>
<td valign="bottom" align="center">27</td>
<td valign="bottom" align="center">5.1</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">3.7</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">5.2</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">8.0</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">T4</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">0.9</td>
<td valign="bottom" align="center">0</td>
<td valign="bottom" align="right">0</td>
<td valign="bottom" align="center">2</td>
<td valign="bottom" align="center">1.2</td>
<td valign="bottom" align="center">3</td>
<td valign="bottom" align="center">2.7</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Unknown</td>
<td valign="bottom" align="center">30</td>
<td valign="bottom" align="center">5.7</td>
<td valign="bottom" align="center">12</td>
<td valign="bottom" align="center">4.9</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">5.2</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">8.0</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">pT</td>
<td valign="bottom" align="left">&lt;= 20mm</td>
<td valign="bottom" align="center">273</td>
<td valign="bottom" align="center">51.7</td>
<td valign="bottom" align="center">154</td>
<td valign="bottom" align="center">63.4</td>
<td valign="bottom" align="center">76</td>
<td valign="bottom" align="center">44.2</td>
<td valign="bottom" align="center">43</td>
<td valign="bottom" align="center">38.1</td>
<td valign="bottom" align="center">&lt;0.0001</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">20-50 mm</td>
<td valign="bottom" align="center">211</td>
<td valign="bottom" align="center">40.0</td>
<td valign="bottom" align="center">73</td>
<td valign="bottom" align="center">30.0</td>
<td valign="bottom" align="center">83</td>
<td valign="bottom" align="center">48.3</td>
<td valign="bottom" align="center">55</td>
<td valign="bottom" align="center">48.7</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">&gt; 50 mm</td>
<td valign="bottom" align="center">44</td>
<td valign="bottom" align="center">8.3</td>
<td valign="bottom" align="center">16</td>
<td valign="bottom" align="center">6.6</td>
<td valign="bottom" align="center">13</td>
<td valign="bottom" align="center">7.6</td>
<td valign="bottom" align="center">15</td>
<td valign="bottom" align="center">13.3</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">pN</td>
<td valign="bottom" align="left">pN0</td>
<td valign="bottom" align="center">332</td>
<td valign="bottom" align="center">62.9</td>
<td valign="bottom" align="center">167</td>
<td valign="bottom" align="center">68.7</td>
<td valign="bottom" align="center">98</td>
<td valign="bottom" align="center">57.0</td>
<td valign="bottom" align="center">67</td>
<td valign="bottom" align="center">59.3</td>
<td valign="bottom" align="center">0.010</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">pN0(i+)</td>
<td valign="bottom" align="center">10</td>
<td valign="bottom" align="center">1.9</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">2.1</td>
<td valign="bottom" align="center">4</td>
<td valign="bottom" align="center">2.3</td>
<td valign="bottom" align="center">1</td>
<td valign="bottom" align="center">0.9</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">pN1mi</td>
<td valign="bottom" align="center">36</td>
<td valign="bottom" align="center">6.8</td>
<td valign="bottom" align="center">17</td>
<td valign="bottom" align="center">7.0</td>
<td valign="bottom" align="center">16</td>
<td valign="bottom" align="center">9.3</td>
<td valign="bottom" align="center">3</td>
<td valign="bottom" align="center">2.7</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">pN1 macro</td>
<td valign="bottom" align="center">144</td>
<td valign="bottom" align="center">27.3</td>
<td valign="bottom" align="center">53</td>
<td valign="bottom" align="center">21.8</td>
<td valign="bottom" align="center">53</td>
<td valign="bottom" align="center">30.8</td>
<td valign="bottom" align="center">38</td>
<td valign="bottom" align="center">33.6</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">no axillary surgery</td>
<td valign="bottom" align="center">6</td>
<td valign="bottom" align="center">1.1</td>
<td valign="bottom" align="center">1</td>
<td valign="bottom" align="center">0.4</td>
<td valign="bottom" align="center">1</td>
<td valign="bottom" align="center">0.6</td>
<td valign="bottom" align="center">4</td>
<td valign="bottom" align="center">3.5</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Grade</td>
<td valign="bottom" align="left">1</td>
<td valign="bottom" align="center">42</td>
<td valign="bottom" align="center">8.0</td>
<td valign="bottom" align="center">26</td>
<td valign="bottom" align="center">10.7</td>
<td valign="bottom" align="center">11</td>
<td valign="bottom" align="center">6.4</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">4.4</td>
<td valign="bottom" align="center">0.065</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">2</td>
<td valign="bottom" align="center">185</td>
<td valign="bottom" align="center">35.0</td>
<td valign="bottom" align="center">87</td>
<td valign="bottom" align="center">35.8</td>
<td valign="bottom" align="center">68</td>
<td valign="bottom" align="center">39.5</td>
<td valign="bottom" align="center">30</td>
<td valign="bottom" align="center">26.5</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">3</td>
<td valign="bottom" align="center">291</td>
<td valign="bottom" align="center">55.1</td>
<td valign="bottom" align="center">125</td>
<td valign="bottom" align="center">51.4</td>
<td valign="bottom" align="center">90</td>
<td valign="bottom" align="center">52.3</td>
<td valign="bottom" align="center">76</td>
<td valign="bottom" align="center">67.3</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">unknown</td>
<td valign="bottom" align="center">10</td>
<td valign="bottom" align="center">1.9</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">2.1</td>
<td valign="bottom" align="center">3</td>
<td valign="bottom" align="center">1.7</td>
<td valign="bottom" align="center">2</td>
<td valign="bottom" align="center">1.8</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">LVI</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">360</td>
<td valign="bottom" align="center">68.2</td>
<td valign="bottom" align="center">167</td>
<td valign="bottom" align="center">68.7</td>
<td valign="bottom" align="center">114</td>
<td valign="bottom" align="center">66.3</td>
<td valign="bottom" align="center">79</td>
<td valign="bottom" align="center">69.9</td>
<td valign="bottom" align="center">0.145</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">130</td>
<td valign="bottom" align="center">24.6</td>
<td valign="bottom" align="center">52</td>
<td valign="bottom" align="center">21.4</td>
<td valign="bottom" align="center">49</td>
<td valign="bottom" align="center">28.5</td>
<td valign="bottom" align="center">29</td>
<td valign="bottom" align="center">25.7</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Unknown</td>
<td valign="bottom" align="center">38</td>
<td valign="bottom" align="center">7.2</td>
<td valign="bottom" align="center">24</td>
<td valign="bottom" align="center">9.9</td>
<td valign="bottom" align="center">9</td>
<td valign="bottom" align="center">5.2</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">4.4</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">Local Recurrence</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">507</td>
<td valign="bottom" align="center">96.0</td>
<td valign="bottom" align="center">233</td>
<td valign="bottom" align="center">95.9</td>
<td valign="bottom" align="center">166</td>
<td valign="bottom" align="center">96.5</td>
<td valign="bottom" align="center">108</td>
<td valign="bottom" align="center">95.6</td>
<td valign="bottom" align="center">0.914</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">21</td>
<td valign="bottom" align="center">4.0</td>
<td valign="bottom" align="center">10</td>
<td valign="bottom" align="center">4.1</td>
<td valign="bottom" align="center">6</td>
<td valign="bottom" align="center">3.5</td>
<td valign="bottom" align="center">5</td>
<td valign="bottom" align="center">4.4</td>
<td valign="bottom" align="center"/>
</tr>
<tr>
<td valign="bottom" align="left">Metastases</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">457</td>
<td valign="bottom" align="center">86.6</td>
<td valign="bottom" align="center">213</td>
<td valign="bottom" align="center">87.7</td>
<td valign="bottom" align="center">153</td>
<td valign="bottom" align="center">89.0</td>
<td valign="bottom" align="center">91</td>
<td valign="bottom" align="center">80.5</td>
<td valign="bottom" align="center">0.099</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">71</td>
<td valign="bottom" align="center">13.4</td>
<td valign="bottom" align="center">30</td>
<td valign="bottom" align="center">12.3</td>
<td valign="bottom" align="center">19</td>
<td valign="bottom" align="center">11.0</td>
<td valign="bottom" align="center">22</td>
<td valign="bottom" align="center">19.5</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Recurrence</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">437</td>
<td valign="bottom" align="center">82.8</td>
<td valign="bottom" align="center">204</td>
<td valign="bottom" align="center">84.0</td>
<td valign="bottom" align="center">146</td>
<td valign="bottom" align="center">84.9</td>
<td valign="bottom" align="center">87</td>
<td valign="bottom" align="center">77.0</td>
<td valign="bottom" align="center">0.181</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">91</td>
<td valign="bottom" align="center">17.2</td>
<td valign="bottom" align="center">39</td>
<td valign="bottom" align="center">16.0</td>
<td valign="bottom" align="center">26</td>
<td valign="bottom" align="center">15.1</td>
<td valign="bottom" align="center">26</td>
<td valign="bottom" align="center">23.0</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Death</td>
<td valign="bottom" align="left">No</td>
<td valign="bottom" align="center">423</td>
<td valign="bottom" align="center">80.1</td>
<td valign="bottom" align="center">204</td>
<td valign="bottom" align="center">84.0</td>
<td valign="bottom" align="center">140</td>
<td valign="bottom" align="center">81.4</td>
<td valign="bottom" align="center">79</td>
<td valign="bottom" align="center">69.9</td>
<td valign="bottom" align="center">0.007</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">Yes</td>
<td valign="bottom" align="center">105</td>
<td valign="bottom" align="center">19.9</td>
<td valign="bottom" align="center">39</td>
<td valign="bottom" align="center">16.0</td>
<td valign="bottom" align="center">32</td>
<td valign="bottom" align="center">18.6</td>
<td valign="bottom" align="center">34</td>
<td valign="bottom" align="center">30.1</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="left">Periods</td>
<td valign="bottom" align="left">&lt; 2005</td>
<td valign="bottom" align="center">138</td>
<td valign="bottom" align="center">26.1</td>
<td valign="bottom" align="center">76</td>
<td valign="bottom" align="center">31.3</td>
<td valign="bottom" align="center">39</td>
<td valign="bottom" align="center">22.7</td>
<td valign="bottom" align="center">23</td>
<td valign="bottom" align="center">20.4</td>
<td valign="bottom" align="center">0.042</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&gt;= 2005</td>
<td valign="bottom" align="center">390</td>
<td valign="bottom" align="center">73.9</td>
<td valign="bottom" align="center">167</td>
<td valign="bottom" align="center">68.7</td>
<td valign="bottom" align="center">133</td>
<td valign="bottom" align="center">77.3</td>
<td valign="bottom" align="center">90</td>
<td valign="bottom" align="center">79.6</td>
<td valign="bottom" align="center">&#xa0;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>AC, adjuvant chemotherapy; ALND, axillary lymph node dissection; cT stage, clinical T stage; ER, endocrine receptor; LVI, lymphovascular invasion; pN, pathologic nodal status; pT, pathologic tumor stage; RNI, regional nodal irradiation; RTH, radiotherapy.</p>
</fn>
<fn>
<p>*Endocrine therapy for ER+Her2+ patients.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s4_2">
<title>Treatments according to age groups</title>
<p>Adjuvant chemotherapy rates were inversely proportional to age (61.7%, 58.7%, and 27.4% in 70-74, 75-80, and &gt; 80 years, respectively (p&lt;0.0001)) (<xref ref-type="supplementary-material" rid="SM1">
<bold>Supplementary Table&#xa0;1</bold>
</xref>). In binary logistic regression, adjuvant chemotherapy was less frequently performed in patients 75-80 years (OR=0.535, p=0.011) and &gt;80 &#x2013;years (OR=0.099, p&lt;0.0001) (<xref ref-type="table" rid="T2">
<bold>Table&#xa0;2</bold>
</xref>). Axillary node assessment (ALND or SLNB alone) was not significantly different according to age groups (<xref ref-type="table" rid="T3">
<bold>Table&#xa0;3</bold>
</xref>). Although mastectomy appeared, at first glance, more frequently used in older patients (28%, 40.7%, and 46% in 70-74, 75-80, and &gt; 80 years, respectively, p=0.001), it turned out not to be influenced by age after adjusting for confounding factors (<xref ref-type="table" rid="T3">
<bold>Tables&#xa0;3</bold>
</xref>, <xref ref-type="table" rid="T4">
<bold>4</bold>
</xref>). Although post-mastectomy radiation therapy (PMRT) administration appeared independent of patients&#x2019; age, patients &gt;80 years were less likely to receive regional nodal irradiation (RNI) (OR=0.281, p=0.001) (<xref ref-type="table" rid="T4">
<bold>Table&#xa0;4</bold>
</xref>). Surprisingly, in 159 HR-positive Her2-positive BC, the endocrine therapy uses decreased with the increasing age group, with a lower rate in patients more than 80 years old (85.1% versus 93.3% and 95.8% in patients 70-74 years and 75-80 years, respectively) approaching statistical significance (p=0.052) (<xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>). Regarding periods of treatment, 138 patients were treated before 2005 (26.1%) and 390 since 2005. Tumor subtypes rates were 60.9% (84/138), 10.9% (15/138) and 28.3% (39/138) before 2005, 48.7% (190/390), 20.5% (80/390) and 30.8% (120/390) since 2005, for TNBC, ER- Her2+ and ER+ Her2+ BC, respectively (p=0.015).</p>
<table-wrap id="T2" position="float">
<label>Table&#xa0;2</label>
<caption>
<p>Adjuvant chemotherapy administration: multivariate analysis.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" colspan="2" rowspan="2" align="left">Adjuvant chemotherapy</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">OR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
</tr>
<tr>
<th valign="middle" align="center">Inferior</th>
<th valign="middle" align="center">Superior</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">
<bold>Grade</bold>
</td>
<td valign="middle" align="left">Grade 1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 2</td>
<td valign="middle" align="center">0.034</td>
<td valign="middle" align="center">2.443</td>
<td valign="middle" align="center">1.068</td>
<td valign="middle" align="center">5.591</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 3</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">6.006</td>
<td valign="middle" align="center">2.626</td>
<td valign="middle" align="center">13.739</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.516</td>
<td valign="middle" align="center">0.465</td>
<td valign="middle" align="center">0.046</td>
<td valign="middle" align="center">4.686</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.09</td>
<td valign="middle" align="center">4.846</td>
<td valign="middle" align="center">0.780</td>
<td valign="middle" align="center">30.117</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">5.647</td>
<td valign="middle" align="center">2.005</td>
<td valign="middle" align="center">15.906</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.026</td>
<td valign="middle" align="center">1.78</td>
<td valign="middle" align="center">5.143</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.013</td>
<td valign="middle" align="center">2.126</td>
<td valign="middle" align="center">1.176</td>
<td valign="middle" align="center">3.844</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.113</td>
<td valign="middle" align="center">1.466</td>
<td valign="middle" align="center">0.914</td>
<td valign="middle" align="center">2.352</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pT</bold>
</td>
<td valign="middle" align="left">pT1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT2</td>
<td valign="middle" align="center">0.008</td>
<td valign="middle" align="center">1.885</td>
<td valign="middle" align="center">1.179</td>
<td valign="middle" align="center">3.013</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">pT3-4</td>
<td valign="middle" align="center">0.738</td>
<td valign="middle" align="center">1.154</td>
<td valign="middle" align="center">0.499</td>
<td valign="middle" align="center">2.670</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>LVI</bold>
</td>
<td valign="middle" align="left">no LVI</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">LVI</td>
<td valign="middle" align="center">0.298</td>
<td valign="middle" align="center">1.324</td>
<td valign="middle" align="center">0.780</td>
<td valign="middle" align="center">2.248</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.065</td>
<td valign="middle" align="center">0.459</td>
<td valign="middle" align="center">0.201</td>
<td valign="middle" align="center">1.050</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.011</td>
<td valign="middle" align="center">0.535</td>
<td valign="middle" align="center">0.331</td>
<td valign="middle" align="center">0.865</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">0.099</td>
<td valign="middle" align="center">0.054</td>
<td valign="middle" align="center">0.184</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>LVI, lymphovascular invasion; pN, pathologic nodal status; pT, pathologic tumor stage; TNBC, triple negative breast cancer.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3" position="float">
<label>Table&#xa0;3</label>
<caption>
<p>Breast and axillary surgery: multivariate analysis.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" colspan="2" rowspan="2" align="left">Mastectomy vs BCS</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">OR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
</tr>
<tr>
<th valign="middle" align="center">Inferior</th>
<th valign="middle" align="center">Superior</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">
<bold>Grade</bold>
</td>
<td valign="middle" align="left">Grade 1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 2</td>
<td valign="middle" align="center">0.017</td>
<td valign="middle" align="center">4.105</td>
<td valign="middle" align="center">1.288</td>
<td valign="middle" align="center">13.084</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 3</td>
<td valign="middle" align="center">0.045</td>
<td valign="middle" align="center">3.249</td>
<td valign="middle" align="center">1.024</td>
<td valign="middle" align="center">10.303</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.209</td>
<td valign="middle" align="center">3.705</td>
<td valign="middle" align="center">0.480</td>
<td valign="middle" align="center">28.590</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.226</td>
<td valign="middle" align="center">2.440</td>
<td valign="middle" align="center">0.576</td>
<td valign="middle" align="center">10.329</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">0.369</td>
<td valign="middle" align="center">1.474</td>
<td valign="middle" align="center">0.632</td>
<td valign="middle" align="center">3.439</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.915</td>
<td valign="middle" align="center">1.796</td>
<td valign="middle" align="center">4.730</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">no surgery</td>
<td valign="middle" align="center">0.188</td>
<td valign="middle" align="center">4.055</td>
<td valign="middle" align="center">0.504</td>
<td valign="middle" align="center">32.633</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.010</td>
<td valign="middle" align="center">2.177</td>
<td valign="middle" align="center">1.203</td>
<td valign="middle" align="center">3.939</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.043</td>
<td valign="middle" align="center">1.683</td>
<td valign="middle" align="center">1.016</td>
<td valign="middle" align="center">2.790</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>cT stage</bold>
</td>
<td valign="middle" align="left">cT0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">1</td>
<td valign="middle" align="center">0.334</td>
<td valign="middle" align="center">0.731</td>
<td valign="middle" align="center">0.387</td>
<td valign="middle" align="center">1.380</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">2</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">4.174</td>
<td valign="middle" align="center">2.239</td>
<td valign="middle" align="center">7.782</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">3</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">12.568</td>
<td valign="middle" align="center">3.674</td>
<td valign="middle" align="center">42.994</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.026</td>
<td valign="middle" align="center">4.255</td>
<td valign="middle" align="center">1.194</td>
<td valign="middle" align="center">15.172</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.352</td>
<td valign="middle" align="center">1.267</td>
<td valign="middle" align="center">0.769</td>
<td valign="middle" align="center">2.088</td>
</tr>
<tr>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">0.337</td>
<td valign="middle" align="center">1.326</td>
<td valign="middle" align="center">0.746</td>
<td valign="middle" align="center">2.356</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>ALND</bold>
</td>
<td valign="middle" align="left">&#xa0;</td>
<td valign="middle" rowspan="2" align="center">p</td>
<td valign="middle" rowspan="2" align="center">OR</td>
<td valign="middle" colspan="2" align="center">CI 95%</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&#xa0;</td>
<td valign="middle" align="center">Inferior</td>
<td valign="middle" align="center">Superior</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.461</td>
<td valign="middle" align="center">1.749</td>
<td valign="middle" align="center">0.396</td>
<td valign="middle" align="center">7.723</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">7.491</td>
<td valign="middle" align="center">3.280</td>
<td valign="middle" align="center">17.110</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">21.941</td>
<td valign="middle" align="center">11.383</td>
<td valign="middle" align="center">42.293</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.935</td>
<td valign="middle" align="center">1.028</td>
<td valign="middle" align="center">0.531</td>
<td valign="middle" align="center">1.989</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.395</td>
<td valign="middle" align="center">0.790</td>
<td valign="middle" align="center">0.459</td>
<td valign="middle" align="center">1.360</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>cT</bold>
</td>
<td valign="middle" align="left">cT0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">1</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.605</td>
<td valign="middle" align="center">1.768</td>
<td valign="middle" align="center">7.349</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">2</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">4.816</td>
<td valign="middle" align="center">2.280</td>
<td valign="middle" align="center">10.176</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">3</td>
<td valign="middle" align="center">0.010</td>
<td valign="middle" align="center">7.766</td>
<td valign="middle" align="center">1.644</td>
<td valign="middle" align="center">36.678</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">4</td>
<td valign="middle" align="center">0.514</td>
<td valign="middle" align="center">2.461</td>
<td valign="middle" align="center">0.164</td>
<td valign="middle" align="center">36.870</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.005</td>
<td valign="middle" align="center">8.246</td>
<td valign="middle" align="center">1.874</td>
<td valign="middle" align="center">36.286</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Surgery</bold>
</td>
<td valign="middle" align="left">BCS</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Mastectomy</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.910</td>
<td valign="middle" align="center">1.701</td>
<td valign="middle" align="center">4.978</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.014</td>
<td valign="middle" align="center">0.044</td>
<td valign="middle" align="center">0.004</td>
<td valign="middle" align="center">0.534</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.636</td>
<td valign="middle" align="center">1.138</td>
<td valign="middle" align="center">0.666</td>
<td valign="middle" align="center">1.943</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">0.479</td>
<td valign="middle" align="center">1.261</td>
<td valign="middle" align="center">0.663</td>
<td valign="middle" align="center">2.398</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>ALND, axillary lymph node dissection; BCS, breast conservative surgery; cT stage, clinical T stage; pN, pathologic nodal status.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T4" position="float">
<label>Table&#xa0;4</label>
<caption>
<p>PMRT and RNI: multivariate analysis.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" colspan="2" rowspan="2" align="left">PMRT</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">OR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
</tr>
<tr>
<th valign="middle" align="center">Inferior</th>
<th valign="middle" align="center">Superior</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.532</td>
<td valign="middle" align="center">1.854</td>
<td valign="middle" align="center">0.267</td>
<td valign="middle" align="center">12.868</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">0.998</td>
<td valign="middle" align="center">2,57E+09</td>
<td valign="middle" align="center">0</td>
<td valign="middle" align="center">.</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">10.345</td>
<td valign="middle" align="center">4.320</td>
<td valign="middle" align="center">24.770</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">no surgery</td>
<td valign="middle" align="center">0.765</td>
<td valign="middle" align="center">0.687</td>
<td valign="middle" align="center">0.058</td>
<td valign="middle" align="center">8.101</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pT</bold>
</td>
<td valign="middle" align="left">pT1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT2</td>
<td valign="middle" align="center">0.018</td>
<td valign="middle" align="center">3.009</td>
<td valign="middle" align="center">1.209</td>
<td valign="middle" align="center">7.485</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">pT3-4</td>
<td valign="middle" align="center">0.114</td>
<td valign="middle" align="center">2.562</td>
<td valign="middle" align="center">0.799</td>
<td valign="middle" align="center">8.217</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>LVI</bold>
</td>
<td valign="middle" align="left">no LVI</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">LVI</td>
<td valign="middle" align="center">0.596</td>
<td valign="middle" align="center">1.288</td>
<td valign="middle" align="center">0.504</td>
<td valign="middle" align="center">3.292</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.835</td>
<td valign="middle" align="center">0.836</td>
<td valign="middle" align="center">0.155</td>
<td valign="middle" align="center">4.508</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.941</td>
<td valign="middle" align="center">0.966</td>
<td valign="middle" align="center">0.385</td>
<td valign="middle" align="center">2.422</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">0.078</td>
<td valign="middle" align="center">0.423</td>
<td valign="middle" align="center">0.162</td>
<td valign="middle" align="center">1.103</td>
</tr>
<tr>
<th valign="bottom" colspan="2" rowspan="2" align="left">Regional Nodal Irradiation
</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">OR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
</tr>
<tr>
<th valign="middle" align="center">Inferior</th>
<th valign="middle" align="center">Superior</th>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.089</td>
<td valign="middle" align="center">3.599</td>
<td valign="middle" align="center">0.823</td>
<td valign="middle" align="center">15.748</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">8.439</td>
<td valign="middle" align="center">3.560</td>
<td valign="middle" align="center">20.009</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">19.218</td>
<td valign="middle" align="center">10.211</td>
<td valign="middle" align="center">36.172</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.707</td>
<td valign="middle" align="center">1.134</td>
<td valign="middle" align="center">0.588</td>
<td valign="middle" align="center">2.186</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.802</td>
<td valign="middle" align="center">0.927</td>
<td valign="middle" align="center">0.515</td>
<td valign="middle" align="center">1.670</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Surgery</bold>
</td>
<td valign="middle" align="left">BCS</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Mastectomy</td>
<td valign="middle" align="center">0.920</td>
<td valign="middle" align="center">1.030</td>
<td valign="middle" align="center">0.578</td>
<td valign="middle" align="center">1.834</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.055</td>
<td valign="middle" align="center">0.089</td>
<td valign="middle" align="center">0.007</td>
<td valign="middle" align="center">1.052</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pT</bold>
</td>
<td valign="middle" align="left">pT1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT2</td>
<td valign="middle" align="center">0.130</td>
<td valign="middle" align="center">1.531</td>
<td valign="middle" align="center">0.882</td>
<td valign="middle" align="center">2.657</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">pT3-4</td>
<td valign="middle" align="center">0.628</td>
<td valign="middle" align="center">1.283</td>
<td valign="middle" align="center">0.469</td>
<td valign="middle" align="center">3.510</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>LVI</bold>
</td>
<td valign="middle" align="left">no LVI</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">LVI</td>
<td valign="middle" align="center">0.238</td>
<td valign="middle" align="center">1.418</td>
<td valign="middle" align="center">0.794</td>
<td valign="middle" align="center">2.533</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.887</td>
<td valign="middle" align="center">1.078</td>
<td valign="middle" align="center">0.380</td>
<td valign="middle" align="center">3.058</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Grade</bold>
</td>
<td valign="middle" align="left">Grade 1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 2</td>
<td valign="middle" align="center">0.906</td>
<td valign="middle" align="center">1.070</td>
<td valign="middle" align="center">0.350</td>
<td valign="middle" align="center">3.272</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Grade 3</td>
<td valign="middle" align="center">0.226</td>
<td valign="middle" align="center">1.943</td>
<td valign="middle" align="center">0.664</td>
<td valign="middle" align="center">5.687</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.986</td>
<td valign="middle" align="center">0.981</td>
<td valign="middle" align="center">0.110</td>
<td valign="middle" align="center">8.712</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.932</td>
<td valign="middle" align="center">1.024</td>
<td valign="middle" align="center">0.585</td>
<td valign="middle" align="center">1.794</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">0.281</td>
<td valign="middle" align="center">0.135</td>
<td valign="middle" align="center">0.583</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>BCS, breast conservative surgery; LVI, lymphovascular invasion; PMRT, post-mastectomy radiotherapy; pN, pathologic nodal status; pT, pathologic tumor stage; RNI, regional nodal irradiation; TNBC, triple negative breast cancer.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s4_3">
<title>Survival results, all patients</title>
<p>Median follow-up was 49 months (mean 51, 95% CI 48.3-53.7), with decreasing values &#x200b;&#x200b;according to the three age groups (56.23, 49, 31.54). In univariate analysis, all patient outcomes (OS, DFS, BCSS, and RFS) significantly decreased as age increased, especially in patients older than 80 years (<xref ref-type="supplementary-material" rid="SM2">
<bold>Supplementary Table&#xa0;2</bold>
</xref>). In multivariate analysis, age &gt;80, pT2-3 sizes, axillary macrometastases, LVI, and HR-negative/Her2-positive tumor subtype, all negatively affected OS (<xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>). Tumor size, axillary macrometastases, and LVI remained independent prognostic factors for DFS, BCSS, and RFS, whereas age &gt; 80 did not. (<xref ref-type="table" rid="T5">
<bold>Table&#xa0;5</bold>
</xref>). When periods were included in multivariate analysis, similar results were observed for patients over 80-years old for OS (HR=3.009, p&lt;0.0001), DFS (HR=2.534, p&lt;0.0001), RFS (HR=1.948, p=0.025) and BCSS (HR=2.255, p=0.030) and better results were observed for period &#x2265; 2005.</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>Kaplan-Meier survival estimates for overall survival in 70-74, 75-80, and &gt;80 years old patients.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fonc-13-1287253-g001.tif"/>
</fig>
<table-wrap id="T5" position="float">
<label>Table&#xa0;5</label>
<caption>
<p>OS, DFS and BCSS: multivariate analysis.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" rowspan="3" align="center"/>
<th valign="bottom" rowspan="3" align="center"/>
<th valign="bottom" colspan="4" align="center">Overall survival</th>
<th valign="bottom" colspan="4" align="center">Disease Free Survival</th>
<th valign="bottom" colspan="4" align="center">Breast Cancer Specific Survival</th>
<th valign="bottom" colspan="4" align="center">Recurrence Free Survival</th>
</tr>
<tr>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">95% CI</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">95% CI</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">95% CI</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">95% CI</th>
</tr>
<tr>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">70-74</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">75-80</td>
<td valign="middle" align="center">0.304</td>
<td valign="middle" align="center">1.291</td>
<td valign="middle" align="center">0.793</td>
<td valign="middle" align="center">2.103</td>
<td valign="middle" align="center">0.457</td>
<td valign="middle" align="center">1.175</td>
<td valign="middle" align="center">0.768</td>
<td valign="middle" align="center">1.797</td>
<td valign="middle" align="center">0.534</td>
<td valign="middle" align="center">0.819</td>
<td valign="middle" align="center">0.438</td>
<td valign="middle" align="center">1.534</td>
<td valign="middle" align="center">0.377</td>
<td valign="middle" align="center">0.793</td>
<td valign="middle" align="center">0.473</td>
<td valign="middle" align="center">1.328</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">&gt;80</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">2.411</td>
<td valign="middle" align="center">1.420</td>
<td valign="middle" align="center">4.095</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.481</td>
<td valign="middle" align="center">1.595</td>
<td valign="middle" align="center">3.860</td>
<td valign="middle" align="center">0.212</td>
<td valign="middle" align="center">1.558</td>
<td valign="middle" align="center">0.777</td>
<td valign="middle" align="center">3.124</td>
<td valign="middle" align="center">0.112</td>
<td valign="middle" align="center">1.576</td>
<td valign="middle" align="center">0.900</td>
<td valign="middle" align="center">2.759</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pT</bold>
</td>
<td valign="middle" align="left">pT1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT2</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.951</td>
<td valign="middle" align="center">2.357</td>
<td valign="middle" align="center">6.621</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.382</td>
<td valign="middle" align="center">1.567</td>
<td valign="middle" align="center">3.622</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.653</td>
<td valign="middle" align="center">1.766</td>
<td valign="middle" align="center">7.558</td>
<td valign="middle" align="center">0.003</td>
<td valign="middle" align="center">2.232</td>
<td valign="middle" align="center">1.318</td>
<td valign="middle" align="center">3.781</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT3-4</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">5.149</td>
<td valign="middle" align="center">2.643</td>
<td valign="middle" align="center">10.030</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.317</td>
<td valign="middle" align="center">1.878</td>
<td valign="middle" align="center">5.856</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">4.952</td>
<td valign="middle" align="center">1.973</td>
<td valign="middle" align="center">12.427</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">3.345</td>
<td valign="middle" align="center">1.646</td>
<td valign="middle" align="center">6.798</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>LVI</bold>
</td>
<td valign="middle" align="left">no LVI</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">LVI</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.272</td>
<td valign="middle" align="center">1.432</td>
<td valign="middle" align="center">3.605</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.148</td>
<td valign="middle" align="center">1.452</td>
<td valign="middle" align="center">3.178</td>
<td valign="middle" align="center">0.002</td>
<td valign="middle" align="center">2.445</td>
<td valign="middle" align="center">1.376</td>
<td valign="middle" align="center">4.343</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.496</td>
<td valign="middle" align="center">1.566</td>
<td valign="middle" align="center">3.978</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.010</td>
<td valign="middle" align="center">2.587</td>
<td valign="middle" align="center">1.261</td>
<td valign="middle" align="center">5.309</td>
<td valign="middle" align="center">0.039</td>
<td valign="middle" align="center">1.997</td>
<td valign="middle" align="center">1.034</td>
<td valign="middle" align="center">3.855</td>
<td valign="middle" align="center">0.817</td>
<td valign="middle" align="center">1.189</td>
<td valign="middle" align="center">0.275</td>
<td valign="middle" align="center">5.144</td>
<td valign="middle" align="center">0.862</td>
<td valign="middle" align="center">0.900</td>
<td valign="middle" align="center">0.274</td>
<td valign="middle" align="center">2.958</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.563</td>
<td valign="middle" align="center">0.550</td>
<td valign="middle" align="center">0.073</td>
<td valign="middle" align="center">4.167</td>
<td valign="middle" align="center">0.714</td>
<td valign="middle" align="center">0.766</td>
<td valign="middle" align="center">0.184</td>
<td valign="middle" align="center">3.185</td>
<td valign="middle" align="center">0.739</td>
<td valign="middle" align="center">1.419</td>
<td valign="middle" align="center">0.182</td>
<td valign="middle" align="center">11.088</td>
<td valign="middle" align="center">0.527</td>
<td valign="middle" align="center">1.601</td>
<td valign="middle" align="center">0.373</td>
<td valign="middle" align="center">6.883</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">0.147</td>
<td valign="middle" align="center">0.406</td>
<td valign="middle" align="center">0.120</td>
<td valign="middle" align="center">1.372</td>
<td valign="middle" align="center">0.119</td>
<td valign="middle" align="center">0.475</td>
<td valign="middle" align="center">0.186</td>
<td valign="middle" align="center">1.210</td>
<td valign="middle" align="center">0.491</td>
<td valign="middle" align="center">0.585</td>
<td valign="middle" align="center">0.127</td>
<td valign="middle" align="center">2.689</td>
<td valign="middle" align="center">0.709</td>
<td valign="middle" align="center">0.814</td>
<td valign="middle" align="center">0.277</td>
<td valign="middle" align="center">2.392</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">0.084</td>
<td valign="middle" align="center">1.536</td>
<td valign="middle" align="center">0.944</td>
<td valign="middle" align="center">2.499</td>
<td valign="middle" align="center">0.034</td>
<td valign="middle" align="center">1.564</td>
<td valign="middle" align="center">1.034</td>
<td valign="middle" align="center">2.364</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">3.019</td>
<td valign="middle" align="center">1.527</td>
<td valign="middle" align="center">5.969</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">2.531</td>
<td valign="middle" align="center">1.495</td>
<td valign="middle" align="center">4.284</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">no surgery</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">6.985</td>
<td valign="middle" align="center">2.678</td>
<td valign="middle" align="center">18.221</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">5.399</td>
<td valign="middle" align="center">2.178</td>
<td valign="middle" align="center">13.381</td>
<td valign="middle" align="center">0.005</td>
<td valign="middle" align="center">9.262</td>
<td valign="middle" align="center">1.956</td>
<td valign="middle" align="center">43.848</td>
<td valign="middle" align="center">0.127</td>
<td valign="middle" align="center">3.164</td>
<td valign="middle" align="center">0.721</td>
<td valign="middle" align="center">13.878</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Chemotherapy</bold>
</td>
<td valign="bottom" align="left">Yes vs No</td>
<td valign="middle" align="center">0.089</td>
<td valign="middle" align="center">0.670</td>
<td valign="middle" align="center">0.422</td>
<td valign="middle" align="center">1.063</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="middle" align="center">0.229</td>
<td valign="middle" align="center">0.689</td>
<td valign="middle" align="center">0.375</td>
<td valign="middle" align="center">1.264</td>
<td valign="middle" align="center">0,079</td>
<td valign="middle" align="center">0.645</td>
<td valign="middle" align="center">0.395</td>
<td valign="middle" align="center">1.052</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
</tr>
<tr>
<td valign="bottom" align="left"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.027</td>
<td valign="middle" align="center">1.800</td>
<td valign="middle" align="center">1.071</td>
<td valign="middle" align="center">3.027</td>
<td valign="bottom" align="center"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
<td valign="bottom" align="left"/>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.080</td>
<td valign="middle" align="center">1.722</td>
<td valign="middle" align="center">0.937</td>
<td valign="middle" align="center">3.165</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
<td valign="bottom" align="left">&#xa0;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>LVI, lymphovascular invasion; pN, pathologic nodal status; pT, pathologic tumor stage; TNBC, triple negative breast cancer.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s4_4">
<title>Comparison between patients 70-80years and 80 years</title>
<p>When aggregating patients in two groups (less or more than 80 years), the univariate analysis still showed older patients to have shorter BCSS (3-year BCSS: 87.7% vs. 88.6%, p=0.006), as well as lower RFS (3-year RFS: 80.5% vs. 88.6%, p&lt;0.0001).</p>
<p>However, after adjusting for tumor and patient characteristics (age, pT, pN, LVI, tumor subtype) and chemotherapy administration, we found no BCSS statistically significant difference in the two age groups (HR=1.633, 95% CI 0.855-3.121, p=0.138), but a worse RFS in patients aged &gt; 80 (HR=1.771, 95% CI 1.055-2.973, p=0.031) (<xref ref-type="fig" rid="f2">
<bold>Figure&#xa0;2</bold>
</xref>). Usual prognostic factors still affected both BCSS and RFS, whereas chemotherapy did not. The tumor subtype impacted BCSS but not RFS (<xref ref-type="table" rid="T6">
<bold>Table&#xa0;6</bold>
</xref>).</p>
<fig id="f2" position="float">
<label>Figure&#xa0;2</label>
<caption>
<p>Kaplan-Meier survival estimates for recurrence-free survival in 70-80 and &gt;80 years old patients.</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fonc-13-1287253-g002.tif"/>
</fig>
<table-wrap id="T6" position="float">
<label>Table&#xa0;6</label>
<caption>
<p>BCSS and RFS: Comparison between patients 70-80 years and &gt; 80-years in multivariate analysis.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="bottom" rowspan="3" align="center"/>
<th valign="bottom" rowspan="3" align="center"/>
<th valign="bottom" colspan="4" align="center">Recurrence Free Survival</th>
<th valign="middle" colspan="4" align="center">Breast Cancer Specific Survival</th>
</tr>
<tr>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
<th valign="middle" rowspan="2" align="center">p</th>
<th valign="middle" rowspan="2" align="center">HR</th>
<th valign="middle" colspan="2" align="center">CI 95%</th>
</tr>
<tr>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
<th valign="middle" align="center">Inf</th>
<th valign="middle" align="center">Sup</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="bottom" align="left">
<bold>Age</bold>
</td>
<td valign="middle" align="left">&gt;80 vs 70-80</td>
<td valign="middle" align="center">0.031</td>
<td valign="middle" align="center">1.771</td>
<td valign="middle" align="center">1.055</td>
<td valign="middle" align="center">2.973</td>
<td valign="middle" align="center">0.138</td>
<td valign="middle" align="center">1.633</td>
<td valign="middle" align="center">0.855</td>
<td valign="middle" align="center">3.121</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pT</bold>
</td>
<td valign="middle" align="left">pT1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pT2</td>
<td valign="middle" align="center">0.002</td>
<td valign="middle" align="center">2.254</td>
<td valign="middle" align="center">1.338</td>
<td valign="middle" align="center">3.798</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">3.705</td>
<td valign="middle" align="center">1.792</td>
<td valign="middle" align="center">7.663</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">pT3</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">3.358</td>
<td valign="middle" align="center">1.666</td>
<td valign="middle" align="center">6.771</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">5.217</td>
<td valign="middle" align="center">2.103</td>
<td valign="middle" align="center">12.940</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>pN</bold>
</td>
<td valign="middle" align="left">pN0</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN0(i+)</td>
<td valign="middle" align="center">0.404</td>
<td valign="middle" align="center">1.870</td>
<td valign="middle" align="center">0.429</td>
<td valign="middle" align="center">8.147</td>
<td valign="middle" align="center">0.698</td>
<td valign="middle" align="center">1.508</td>
<td valign="middle" align="center">0.189</td>
<td valign="middle" align="center">12.012</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1mi</td>
<td valign="middle" align="center">0.758</td>
<td valign="middle" align="center">0.844</td>
<td valign="middle" align="center">0.287</td>
<td valign="middle" align="center">2.483</td>
<td valign="middle" align="center">0.534</td>
<td valign="middle" align="center">0.613</td>
<td valign="middle" align="center">0.131</td>
<td valign="middle" align="center">2.866</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">pN1macro</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.601</td>
<td valign="middle" align="center">1.545</td>
<td valign="middle" align="center">4.380</td>
<td valign="middle" align="center">0.001</td>
<td valign="middle" align="center">3.077</td>
<td valign="middle" align="center">1.564</td>
<td valign="middle" align="center">6.057</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">no surgery</td>
<td valign="middle" align="center">0.186</td>
<td valign="middle" align="center">2.726</td>
<td valign="middle" align="center">0.616</td>
<td valign="middle" align="center">12.066</td>
<td valign="middle" align="center">0.010</td>
<td valign="middle" align="center">7.722</td>
<td valign="middle" align="center">1.616</td>
<td valign="middle" align="center">36.892</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Chemotherapy</bold>
</td>
<td valign="middle" align="left">No vs Yes</td>
<td valign="middle" align="center">0.139</td>
<td valign="middle" align="center">0.688</td>
<td valign="middle" align="center">0.420</td>
<td valign="middle" align="center">1.128</td>
<td valign="middle" align="center">0.302</td>
<td valign="middle" align="center">0.725</td>
<td valign="middle" align="center">0.394</td>
<td valign="middle" align="center">1.335</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>LVI</bold>
</td>
<td valign="middle" align="left">No</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">Yes</td>
<td valign="middle" align="center">&lt;0.0001</td>
<td valign="middle" align="center">2.589</td>
<td valign="middle" align="center">1.619</td>
<td valign="middle" align="center">4.141</td>
<td valign="middle" align="center">0.002</td>
<td valign="middle" align="center">2.515</td>
<td valign="middle" align="center">1.409</td>
<td valign="middle" align="center">4.487</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">unknown</td>
<td valign="middle" align="center">0.898</td>
<td valign="middle" align="center">0.925</td>
<td valign="middle" align="center">0.281</td>
<td valign="middle" align="center">3.049</td>
<td valign="middle" align="center">0.742</td>
<td valign="middle" align="center">1.281</td>
<td valign="middle" align="center">0.294</td>
<td valign="middle" align="center">5.593</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>Subtype</bold>
</td>
<td valign="middle" align="left">TNBC</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">1</td>
<td valign="middle" align="center">&#xa0;</td>
<td valign="middle" align="center">&#xa0;</td>
</tr>
<tr>
<td valign="bottom" align="center"/>
<td valign="middle" align="left">ER- Her2+</td>
<td valign="middle" align="center">0.100</td>
<td valign="middle" align="center">0.599</td>
<td valign="middle" align="center">0.325</td>
<td valign="middle" align="center">1.102</td>
<td valign="middle" align="center">0.361</td>
<td valign="middle" align="center">0.737</td>
<td valign="middle" align="center">0.382</td>
<td valign="middle" align="center">1.419</td>
</tr>
<tr>
<td valign="bottom" align="left">
<bold>&#xa0;</bold>
</td>
<td valign="middle" align="left">ER+ Her2+</td>
<td valign="middle" align="center">0.156</td>
<td valign="middle" align="center">0.696</td>
<td valign="middle" align="center">0.422</td>
<td valign="middle" align="center">1.148</td>
<td valign="middle" align="center">0.025</td>
<td valign="middle" align="center">0.453</td>
<td valign="middle" align="center">0.226</td>
<td valign="middle" align="center">0.905</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>BCSS, breast cancer specific survival; LVI, lymphovascular invasion; pN, pathologic nodal status; pT, pathologic tumor stage; RFS, recurrence free survival; TNBC, triple negative breast cancer.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s4_5">
<title>Patients with pT1, pN0 or pN0(i+) or pN1mi, TNBC or Her2-positive</title>
<p>We conducted the same analyses in the three age groups restricted to small tumors (pT1) with no or low nodal involvement (pN0-1mi) to find out whether de-escalation in adjuvant treatments can negatively impact elderly patients&#x2019; outcomes.</p>
<p>Two hundred thirty-four patients had pT1pN0-1mi TN (129), HR-Her2+ (30), or ER+Her2+ (75) BC, homogeneously represented in each age group (p=0.461), with 212 patients having pN0 disease (90.6%), 6 pN0(i+) (2.6%) and 16 pN1mi (6.8%) (<xref ref-type="supplementary-material" rid="SM3">
<bold>Supplementary Table&#xa0;3</bold>
</xref>). In binary logistic regression, age &gt;80 years was significantly associated with less adjuvant chemotherapy administration (OR=0.217, 95% CI 0.08-0.58, p=0.002). Adjuvant chemotherapy administration was significantly associated with pN1mi (OR=9.647, 2.01-46.22, p=0.005) and HR-negative Her2-positive subtype (OR=2.790, 1.12-6.94, p=0.027), without significant association with age 75-80 (OR=0.631, 0.32-1.23, p=0.179), pN0(i+), HR-positive Her2-positive BC and with LVI.</p>
<p>With a median follow-up was 55 months (mean 56.8, 95% CI 52.7-60.8), OS, DFS, and BCSS were not significantly different in the three age groups on multivariate analysis, whereas RFS tended to be lower in &gt; 80 years patients (HR= 2.392, 95% CI: 0.893-6.410, p=0.083) (<xref ref-type="supplementary-material" rid="SF2">
<bold>Supplementary Figure&#xa0;2</bold>
</xref>).</p>
</sec>
</sec>
<sec id="s5" sec-type="discussion">
<title>Discussion</title>
<p>More than 50% of early-stage breast cancers are diagnosed in women aged more than 65 years, and &gt;30% over the age of 70 years with these proportions in constant rise (<xref ref-type="bibr" rid="B32">32</xref>, <xref ref-type="bibr" rid="B33">33</xref>). Elderly patients display higher rates of HR-positive/Her2-negative BC compared to TN and Her2-positive subtypes. Due to underrepresentation in clinical trials, only a few data dedicated to TN and Her2-positive elderly BC patients are available. We reported here histoclinical characteristics, treatments, and outcomes in 528 BC patients &#x2265;70 years old including 274 with TN subtype and 254 with Her2-positive.</p>
<sec id="s5_1">
<title>Elderly patient characteristics</title>
<p>Consistently with available reports, our study found older patients having more advanced disease (but also more favorable prognostic factors, such as lower grade and LVI, and more frequently HR-positive tumors) (<xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B13">13</xref>&#x2013;<xref ref-type="bibr" rid="B17">17</xref>). We also found larger tumor size and lymph node involvement with increasing age. TN and Her2-positive were well balanced in elderly patients, being way less frequent than HR-positive/Her2-negative subtype, as reported in two large series. Plichta et&#xa0;al. (<xref ref-type="bibr" rid="B34">34</xref>) described a series of 156,240 &#x2264;45 years patients and 210,095 &#x2265;75 years patients, finding a TN rate of 14.9% vs. 8.2%, and a Her2-positive rate of 18.6% vs. 9.2%, respectively. Similarly, it was reported in a recent study including 235,368 early breast cancer patients, that the BC subtype distribution differs according to age, with an increase of Luminal BC and decrease of TNBC, Her-positive/HR-positive and Her2-positive/HR-negative BC, with higher age: 46.9%, 29.7%, 15.9%, and 7.5% respectively for age &lt;30-years; 87%, 6.2%, 4.1% and 2.7% respectively for age 70-79 years; and 93.4%, 2.7%, 2.2% and 1.7% for patients age 80-years or older (<xref ref-type="bibr" rid="B35">35</xref>).</p>
</sec>
<sec id="s5_2">
<title>Elderly patient management</title>
<p>Existing studies have reported elderly patients&#x2019; outcomes according to adjuvant treatment delivery, but only a few focused on TN and Her2-positive BC. Elderly patients are often undertreated due to multiple comorbidities as well as patients&#x2019; or relatives&#x2019; wishes. Jauhari et&#xa0;al. (<xref ref-type="bibr" rid="B36">36</xref>) recently reported as much as 5.6%, 11%, and 41.9% of surgery omission in 70-74, 75-79, and &#x2265; 80 years HR-positive BC patients, respectively, dropping to 3.8%, 3.7%, and 12.3% in HR-negative BC patients. Similar tendencies arose from the National Audit of Breast Cancer in Older Patients (NABCOP) (<xref ref-type="bibr" rid="B37">37</xref>) and National Health Service (NHS) (<xref ref-type="bibr" rid="B38">38</xref>). In a recent study of early breast cancer patients (<xref ref-type="bibr" rid="B35">35</xref>), surgery followed by chemotherapy was realized in 43.4% of all tumor subtypes, and neo-adjuvant chemotherapy in 30.9% (25.7% surgery without chemotherapy) for patients under 30 years; 21% and 2.9% (74.7%) and 1.6% of neo-adjuvant endocrine therapy for patients 70-79 years; 6.3% and 1.1% (87.2%) and 5.4% of neo-adjuvant endocrine therapy for patients 80-years or older. A common strategy in this patient population appears to rely on neo-adjuvant endocrine therapy in HR-positive in more or less debilitated patients, deemed with a short life expectancy (<xref ref-type="bibr" rid="B36">36</xref>, <xref ref-type="bibr" rid="B39">39</xref>). Since we limited our study to patients referred for surgery, our data do not help in discussing this strategy. Nonetheless, contrary to several reports (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B40">40</xref>&#x2013;<xref ref-type="bibr" rid="B43">43</xref>), the type of surgery, including lymph node assessment, was independent of patients&#x2019; age in our study. This point is worth emphasizing since axillary surgery in clinically node-negative elderly patients remains moot. Indeed, axillary surgery, whether an ALND or even an SLNB, caters to some unneglectable adverse events (pain, numbness, loss of strength, decreased motion (<xref ref-type="bibr" rid="B44">44</xref>), which could substantially alter older patients&#x2019; quality of life. However, Corso G et&#xa0;al. (<xref ref-type="bibr" rid="B45">45</xref>) reported a matched analysis comparing axillary surgery to its omission in patients aged 70 years or older, stratified by age (70-74, 75-79, 80-84), with a significantly increased 10-y-risk of axillary lymph node recurrence, particularly in Luminal B, Her2-positive, and TNBC. Similarly, Marks et&#xa0;al. (<xref ref-type="bibr" rid="B46">46</xref>) showed that in an upfront surgery cohort of clinically node-positive elderly BC patients, the presence of less than 12 lymph nodes was associated with worse OS. Still, in a 1996 randomized trial (<xref ref-type="bibr" rid="B47">47</xref>), Avril et&#xa0;al. failed to show the safety of axillary assessment omission in early BC elderly patients. Nonetheless, several ongoing trials are currently evaluating SLNB omission in elderly patients with HR-positive BC. Although more frequent in higher-age patients in our univariate analysis, mastectomy was independent of age in multivariate analysis. Studies from a decade ago suggested that mastectomy prevails over breast-conserving surgery in elderly patients (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B15">15</xref>, <xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B22">22</xref>, <xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B48">48</xref>), likely in the hope of avoiding adjuvant radiation therapy. Similarly, Jauhari et&#xa0;al. study (<xref ref-type="bibr" rid="B49">49</xref>) found the rate of mastectomy to increase with age (70&#x2013;74, 75&#x2013;79, and &#x2265; 80 years), irrespective of ER status. However, when comparing young (&#x2264; 45 years) to elderly (&#x2265; 75 years) patients, Plichta et&#xa0;al. (<xref ref-type="bibr" rid="B34">34</xref>) found the mastectomy rate to be higher in young patients (56% vs. 34%).</p>
<p>After breast-conserving surgery, adjuvant radiation therapy is standard of care since it improves the loco-regional recurrence rate and OS (EBCTCG 2014). Nonetheless, several studies reported on adjuvant radiation-therapy omission in the elderly due to fear of radiation toxicity and issues in transportation and mobility (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B20">20</xref>, <xref ref-type="bibr" rid="B21">21</xref>, <xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B48">48</xref>, <xref ref-type="bibr" rid="B50">50</xref>). Several randomized studies in this setting have constantly found adjuvant radiation therapy to significantly improve local control without any impact on OS (<xref ref-type="bibr" rid="B51">51</xref>&#x2013;<xref ref-type="bibr" rid="B57">57</xref>). On the other hand, a recent report by Tang et&#xa0;al. (<xref ref-type="bibr" rid="B58">58</xref>) showed that only 4.8% of elderly patients chose to decline adjuvant radiation therapy when asked for their preferred treatment option. PMRT still causes debates, even in young BC patients. Although the EBCTCG meta-analysis demonstrated its benefit in T1-2N1 BC patients who received chemotherapy (<xref ref-type="bibr" rid="B59">59</xref>), profuse literature data is currently challenging its actual need in intermediate-risk patients, irrespective of patient age. In our multicenter study, neither surgery nor adjuvant radiation therapy was altered by patient age, except RNI, which was less likely to be offered to older patients.</p>
<p>International guidelines recommend adjuvant chemotherapy (and Trastuzumab) in most patients with HR-negative or Her2-positive disease (<xref ref-type="bibr" rid="B60">60</xref>). In our study, we observed fewer adjuvant chemotherapy in patients 75-80 years (OR=0.533) and &gt;80&#x2013;years (OR=0.106). Few clinical trials have focused on elderly patients, and recommendations rely on the extrapolation of studies conducted in the general population, including a small proportion of elderly patients (<xref ref-type="bibr" rid="B61">61</xref>, <xref ref-type="bibr" rid="B62">62</xref>). Multimorbidity competes with cancer on the outcome and the therapeutic ratio is narrower because they are at higher risk of side effects in this population. Recently, the results of the large phase III Unicancer ASTER 70s study have been reported (<xref ref-type="bibr" rid="B63">63</xref>). Brain and colleagues have shown that the addition of adjuvant chemotherapy to endocrine therapy does not result in a statistically significant overall survival (OS) benefit in patients older than 70 years with estrogen receptor (ER)-positive, Her2-negative breast cancer with a high tumor genomic grade index. However, in the CALGB 49907 study (<xref ref-type="bibr" rid="B64">64</xref>), adjuvant chemotherapy for patients over 65 years showed a beneficial impact, and the greatest benefit was reported in TNBC. In elderly patients, adjuvant treatment administration mainly depends on patient choice and associated comorbidities that may reduce tolerance and compliance with adjuvant treatments (<xref ref-type="bibr" rid="B19">19</xref>, <xref ref-type="bibr" rid="B65">65</xref>&#x2013;<xref ref-type="bibr" rid="B68">68</xref>). Moreover, toxicity prediction is challenging, and in a randomized trial, none of the multiple geriatric scores predicted tolerance of therapy (<xref ref-type="bibr" rid="B69">69</xref>). There is an increased likelihood of side effects, hospital admissions, and short-term mortality in elderly patients (<xref ref-type="bibr" rid="B70">70</xref>, <xref ref-type="bibr" rid="B71">71</xref>).</p>
</sec>
<sec id="s5_3">
<title>Elderly patient outcomes</title>
<p>OS and DFS were significantly associated with age &gt; 80 years but without significant difference between age groups for BCSS. However, RFS was significantly lower for patients &gt; 80 years in comparison with patients 70-80 years. For patients with pT1, pN0 or pN0(i+) or pN1mi BC, adjuvant chemotherapy administration was significantly associated and lower with age &gt; 80 years (OR=0.217) but there was no significant OS, DFS, and BCSS difference between three age groups. We reported that systemic treatments were less likely to be administered to older patients. Multivariate analysis conducted on the whole population study found that age &#x2265; 80 did not affect BCSS or RFS, meaning that worse outcomes observed in this age population in the univariate analysis came from other prognostic factors, such as tumor size and lymph node involvements. Several studies suggest that adjuvant therapy may have a beneficial impact on patients with high-risk BC (node-positive or HR-negative) (<xref ref-type="bibr" rid="B39">39</xref>, <xref ref-type="bibr" rid="B72">72</xref>&#x2013;<xref ref-type="bibr" rid="B75">75</xref>). Higher BC recurrence rate (<xref ref-type="bibr" rid="B14">14</xref>, <xref ref-type="bibr" rid="B48">48</xref>), higher distant recurrence rate (<xref ref-type="bibr" rid="B76">76</xref>), lower DFS and OS rates (<xref ref-type="bibr" rid="B16">16</xref>, <xref ref-type="bibr" rid="B22">22</xref>), and higher disease-specific mortality (<xref ref-type="bibr" rid="B48">48</xref>) had been reported in elderly BC patients, whatever tumor subtypes. In 2002 patients &#x2265; 75 years matched by clinic-pathological and therapeutic factors, chemotherapy was associated with improved OS in Her2-positive BC but not in TNBC (<xref ref-type="bibr" rid="B77">77</xref>). In multivariate Cox survival analysis of 16,062 patients &#x2265; 70 years with resected TNBC, a beneficial impact of chemotherapy was observed for all groups of patients according to age subdivided into 5-year tranches and for TNBC with tumor size more than 20mm (<xref ref-type="bibr" rid="B78">78</xref>). Moreover, a propensity-matched analysis including 1,884 patients with TNBC, compared patients who received chemotherapy with those who were recommended to but did not receive chemotherapy and reported an OS improvement with chemotherapy (HR=0.69, 95% CI 0.60-0.80, p&lt;0.0001). This benefit persisted after stratification for node-negative BC (HR=0.80, p=0.007), node-positive BC (HR=0.76, p=0.006), and those with a comorbidity score &gt;0 (HR=0.74, p=0.013). In the same way, Tang et&#xa0;al. (<xref ref-type="bibr" rid="B79">79</xref>) have shown in elderly primary operable TNBC patients (&#x2265;70 years old) that age (HR=1.03 per year, p&lt;0.001), T1c (HR=2.95) and chemotherapy (HR=0.79, p=0.035) were associated with lesser cancer-specific survival.</p>
<p>Although adjuvant trastuzumab is beneficial regardless of age, anti-Her2 adjuvant therapy remains only little evaluated in elderly patients (<xref ref-type="bibr" rid="B80">80</xref>, <xref ref-type="bibr" rid="B81">81</xref>). The standard approach in elderly patients with early Her2-positive BC is one year of trastuzumab, combined with chemotherapy including docetaxel or weekly paclitaxel. However, the use of chemotherapy-free regimen can be proposed in frail patients (<xref ref-type="bibr" rid="B82">82</xref>), considering that age is associated with increased cardiac toxicity, particularly for patients aged 80 years or older with comorbidities (<xref ref-type="bibr" rid="B83">83</xref>, <xref ref-type="bibr" rid="B84">84</xref>). Endocrine therapy is indicated in HR-positive BC, regardless of age, with aromatase inhibitors for 5 years, but could be omitted in patients with very low risk (<xref ref-type="bibr" rid="B85">85</xref>).</p>
<p>Our analysis in 234 pT1 pN0/1mi identified higher rates of chemotherapy in patients &#x2264;80 years, with HR-negative Her2-positive, and with pN1mi tumors. OS, DFS, RFS, and OS were not significatively impacted by age groups. Only a few data have been reported regarding patients with small tumors without macroscopic lymph node involvements, and we noted in a previous study that tumor size may not be the main prognostic factor in T1 BC (<xref ref-type="bibr" rid="B86">86</xref>). While the need for trastuzumab-based adjuvant chemotherapy may be disputed in pT1a-b HR-positive/Her2-positive tumors (<xref ref-type="bibr" rid="B30">30</xref>, <xref ref-type="bibr" rid="B87">87</xref>), chemotherapy is rarely omitted in node-negative TN BC larger than 5 mm. However, we recently failed to identify a significant advantage for adjuvant chemotherapy in pT1abN0 TNBC patients (<xref ref-type="bibr" rid="B29">29</xref>) and this systemic treatment might be discussed for elderly patients with tumors &lt;1cm.</p>
<p>Our study has several limitations. Due to the retrospective design of the study, some valuable variables are missing from our analysis, including details of chemotherapy protocols on this 27-years&#x2019; time frame, collection of geriatric data, quality of life data, treatment acceptability, and socioeconomic data. Indeed, the study sample might be biased by the selection of patients eligible to surgery. The lack of data on patients comorbidities might be one of the principal limitations in this elderly population, because of the potential increase in the risk of chemotherapy-related complications, the effect on patients outcomes, as well as the influence that can occurs on treatment adaptations.</p>
</sec>
</sec>
<sec id="s6" sec-type="conclusion">
<title>Conclusion</title>
<p>TN and Her2-positive subtypes occur at a similar frequency in elderly patients. Older age is associated with more advanced tumor stage presentation. Chemotherapy use decreases with older age without being affected by other pejorative prognostic factors. This may reflect oncologists&#x2019; uncertainty when making management decisions in elderly patients, and the need to optimize BC management for these patients who may be fit, but where multimorbidity may also compete with cancer on outcomes.</p>
</sec>
<sec id="s7" sec-type="data-availability">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/<xref ref-type="supplementary-material" rid="SM1">
<bold>Supplementary Material</bold>
</xref>. Further inquiries can be directed to the corresponding author.</p>
</sec>
<sec id="s8" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>The studies involving humans were approved by strategic orientation committee of Paoli-Calmettes Institute. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants&#x2019; legal guardians/next of kin in accordance with the national legislation and institutional requirements.</p>
</sec>
<sec id="s9" sec-type="author-contributions">
<title>Author contributions</title>
<p>GH: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. MC: Resources, Writing &#x2013; review &amp; editing. AG: Resources, Writing &#x2013; review &amp; editing. AB: Resources, Writing &#x2013; review &amp; editing. MPC: Resources, Writing &#x2013; review &amp; editing. CF: Resources, Writing &#x2013; review &amp; editing. JC: Resources, Writing &#x2013; review &amp; editing. EJ: Resources, Writing &#x2013; review &amp; editing. LS: Resources, Writing &#x2013; review &amp; editing. MB: Resources, Writing &#x2013; review &amp; editing. LT: Resources, Writing &#x2013; review &amp; editing. MM: Resources, Writing &#x2013; review &amp; editing. AT: Resources, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing. AN: Conceptualization, Resources, Validation, Visualization, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing.</p>
</sec>
</body>
<back>
<sec id="s10" sec-type="funding-information">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec id="s11" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
<p>The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.</p>
</sec>
<sec id="s12" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec id="s13" sec-type="supplementary-material">
<title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/fonc.2023.1287253/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/fonc.2023.1287253/full#supplementary-material</ext-link>
</p>
<supplementary-material xlink:href="Image_1.tif" id="SF1" mimetype="image/tiff">
<label>Supplementary Figure&#xa0;1</label>
<caption>
<p>Consort diagram showing patients selection.</p>
</caption>
</supplementary-material>
<supplementary-material xlink:href="Image_2.tiff" id="SF2" mimetype="image/tiff">
<label>Supplementary Figure&#xa0;2</label>
<caption>
<p>Kaplan-Meier survival estimates for recurrence-free survival in 70-80 and &gt;80 years old patients with pT1 pN0, pN0(i+), and pN1mi tumors.</p>
</caption>
</supplementary-material>
<supplementary-material xlink:href="Table_1.docx" id="SM1" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document">
<label>Supplementary Table&#xa0;1</label>
<caption>
<p>Factors associated with adjuvant chemotherapy in univariate analysis.</p>
</caption>
</supplementary-material>
<supplementary-material xlink:href="Table_1.docx" id="SM2" mimetype="application/vnd.openxmlformats-officedocument.wordprocessingml.document">
<label>Supplementary Table&#xa0;2</label>
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<p>Overall Survival, Disease-Free Survival, Breast Cancer Specific Survival, and Recurrence Free Survival results in univariate analysis.</p>
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</supplementary-material>
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<p>Characteristics of 234 patients pT1 pN0, pN0(i+), pN1mi and adjuvant chemotherapy administration.</p>
</caption>
</supplementary-material>
</sec>
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