AUTHOR=Zhang Xiaofei , Ma Li , Wan Li , Wang Haoran , Wang Zhaoxia 

TITLE=Circ_0003945: an emerging biomarker and therapeutic target for human diseases

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1275009

DOI=10.3389/fonc.2024.1275009

ISSN=2234-943X

ABSTRACT=Due to the rapid development of RNA sequencing techniques, a circular noncoding RNA (ncRNA) known as circular RNAs (circRNAs) has gradually come Into focus. As a distinguished member of the circRNA family, circ_0003945 has garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that circ_0003945 could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug-resistance, and radio-resistance through the molecular mechanism of competitive endogenous RNA (ceRNA) during tumorigenesis. The expression of circ_0003945 is frequently associated with some clinical parameters and implies a poorer prognosis in the majority of cancers. In non-malignant conditions, circ_0003945 also holds considerable importance in diseases pathogenesis. This review aims to recapitulate molecular mechanism of circ_0003945 and elucidates its potential as a diagnostic and therapeutic target in neoplasms and other diseases.