AUTHOR=Lopez Aguilar Enrique , Del Campo Martinez Angeles , Rioscovian Soto Ana , Ayala-Contreras Karen , Zapata-Tarrés Marta , Cuéllar Mendoza Miguel Enrique , Betanzos Cabrera Yadira , Zevada-Mosti Regina , Payán Romo Sheyla , Esquer Cota Oscar Omar , Zazueta Mérida Pamela , Anaya Aguirre Susana Elizabeth , Rodríguez Cedeño Emmanuel Rolando , Gutiérrez Rivera Maria De Lourdes , Martín Trejo Jorge Alfonso , Mayorga Castillo Elvia Yaroslab , Contreras Camacho Carolina , Reyes Espinoza Elio Aaron , Alatoma Medina Norma Eryca , Tiznado García Hector Manuel , Santillán Ávila Christian , Sepúlveda Núñez Jose Maria , Fuerte Olvera Sadya , Rodríguez Brindis Lizeth , Parra Salazar Jose Alvaro , García Stivalet Lilia Adela , Bojórquez Steffani Lizette , Betancourt Ortiz Roberto Abraham , Treviño Aurora , Mercado Castruita Julio , Aburto Mejia Rocio , Jimenez Salinas Adrian , Valdivia Ibarra Francisco Javier , Zepeda Arias Fabiana Maribel , Figueroa Rosas Ana Leticia , Sagarnaga Durante Desiree , Borrego Perez Fatima , Urbina Ochoa Jorge Humberto , Prieto Torres Gustavo Ignacio , Chavez Martenez Jose De Jesus , Perez Soltero Juan Gilberto , Careaga Reyna Guillermo , Ramos Hernandez Ma. Teresa Cristina , Cardenas Navarrete Rocio , Gonzalez Rosas Elsa Fabiola , Pineda Gordillo Adolfo , Ochoa-Drucker Cecilia , López Facio Enrique , Rios Osuna Mirna Guadalupe , Portillo Zavala Claudia Selene , Cobo Ovando Sergio Ruben , Aguilar Román A. B. , Chávez Liñán Brenda , Arroyo Acosta Benjamin , Bernabe-Gaspar Luis E. , Rivera Ramírez A. B. , Malváez Estrada D. A. , Ulloa Salaices E. , Silva Delfín V. P. , González Villarreal G. , Estolando Ayón M. , Muñoz Flores Aaron , Ortiz de la O E. F. , Ortiz Trujillo H. J. , Moreno Domínguez José Luis , Lopez Suastegui Miguel , Gallegos Cruz L. , Duque-Molina Celida 

TITLE=Equitable access to a personalized treatment with the OncoCREAN national strategy in pediatric patients with acute lymphoblastic leukemia from the Mexican Social Security Institute

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1304640

DOI=10.3389/fonc.2024.1304640

ISSN=2234-943X

ABSTRACT=IntroductionThe Mexican Social Security Institute (IMSS) was created in 1943 as the main public institution in Mexico.MethodsIn 2020, the OncoCREAN (Centros de Referencia Estatal para la Atención del Niño y de la Niña con Cáncer) strategy was established and consists of reference centers of Pediatric Oncology created to provide equitable access to pediatric patients with cancer in Mexico and toimprove the disease survival through standardized immunophenotyping, harmonized diagnosis, homogenized treatment, staff training, and complication response.ResultsAt 12 months of follow-up, overall survival is 89.9% in pediatric patients with acute lymphoblastic leukemia; we have no early death, and the main cause of death is still infection.DiscussionThe current procedure in terms of immune molecular diagnosis is to send samples to the first national system of samples reference for the immunological diagnosis of leukemias based on immunophenotyping in the Cytomics Laboratory of the IMSS Research Center in Puebla, as a strong collaborative alliance. We present a narrative description of the strategy as preliminary results.