AUTHOR=Wang Jiaxi , Wang Xingyu , Yin Wanjun , Zhang Shiqian 

TITLE=Survival impact and safety of intrathoracic and abdominopelvic cytoreductive surgery in advanced ovarian cancer: a systematic review and meta-analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1335883

DOI=10.3389/fonc.2024.1335883

ISSN=2234-943X

ABSTRACT=Purpose Achieving no residual disease is essential for ovarian cancer patients to prolongincreasing overall survival (OS) and progressprogression-free survival (PFS) in ovarian cancer patients. However, the survival benefit fromof achieving no residual disease induring both intrathoracic and abdominopelvic cytoreductive surgery is still unclear. This meta-analysis aimsaimed to assess the survival benefit and safety of intrathoracic and abdominopelvic cytoreductive surgery in advanced ovarian cancer patients. Methods We systematically searched for studies in online databases, including PubmedPubMed, Embase, and Web of Science. We used Q statistics and the I-squared statistics to evaluate the heterogeneity, sensitivity analysis to test the origin of heterogeneity, and Egger's and Begg's tests to evaluate publication bias. Results We included 4 retrospective cohort studies, including 490 patients, infor analysis, which; these studies were assessed as high-quality studies. The combined hazard ratio (HR) with 95% confidence interval (CI) for OS was 1.92 (95%CI95% CI 1.38-2.68), while the combined HR for PFS was 1.91 (95%CI95% CI 1.47-2.49). Only 19 patients amongin the four studies were reported with major complications, and 4 of these complications were surgery-related. Conclusions Maximal effortThe maximal extent of cytoreduction in the intrathoracic and abdominopelvic tract improves the survival outcomes, including OS and PFS, in advanced ovarian cancer patients with acceptable complications.