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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Oncol.</journal-id>
<journal-title>Frontiers in Oncology</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Oncol.</abbrev-journal-title>
<issn pub-type="epub">2234-943X</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/fonc.2024.1347896</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Oncology</subject>
<subj-group>
<subject>Case Report</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Tislelizumab induced dual organs dysfunction in a patient with advanced esophageal squamous cell carcinoma: a case report</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Yang</surname>
<given-names>Bo</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1959598"/>
<role content-type="https://credit.niso.org/contributor-roles/funding-acquisition/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gou</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
<role content-type="https://credit.niso.org/contributor-roles/investigation/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lan</surname>
<given-names>Naiying</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
<role content-type="https://credit.niso.org/contributor-roles/investigation/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Shao</surname>
<given-names>Qing</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
<role content-type="https://credit.niso.org/contributor-roles/investigation/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hu</surname>
<given-names>Weifeng</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/data-curation/"/>
<role content-type="https://credit.niso.org/contributor-roles/investigation/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Xue</surname>
<given-names>Cheng</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/1802874"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Liu</surname>
<given-names>Nanmei</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>*</sup>
</xref>
<role content-type="https://credit.niso.org/contributor-roles/conceptualization/"/>
<role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/>
</contrib>
</contrib-group>    <aff id="aff1">
<sup>1</sup>
<institution>Internal Medicine III (Nephrology), Naval Medical Center of PLA, Naval Medical University</institution>, <addr-line>Shanghai</addr-line>, <country>China</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>Department of Nephrology and Endocrinology, Shanghai 411 Hospital, Shanghai University</institution>, <addr-line>Shanghai</addr-line>, <country>China</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>Division of Nephrology, Changzheng Hospital, Naval Medical University</institution>, <addr-line>Shanghai</addr-line>, <country>China</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>Edited by: Cornelis F.M. Sier, Leiden University, Netherlands</p>
</fn>
<fn fn-type="edited-by">
<p>Reviewed by: Alexandre O. G&#xe9;rard, Centre Hospitalier Universitaire de Nice, France</p>
<p>Mohamed Rahouma, NewYork-Presbyterian, United States</p>
</fn>
<fn fn-type="corresp" id="fn001">
<p>*Correspondence: Cheng Xue, <email xlink:href="mailto:chengxia1568@126.com">chengxia1568@126.com</email>; Nanmei Liu, <email xlink:href="mailto:13585996275@163.com">13585996275@163.com</email>
</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>14</day>
<month>03</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="collection">
<year>2024</year>
</pub-date>
<volume>14</volume>
<elocation-id>1347896</elocation-id>
<history>
<date date-type="received">
<day>01</day>
<month>12</month>
<year>2023</year>
</date>
<date date-type="accepted">
<day>05</day>
<month>03</month>
<year>2024</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2024 Yang, Gou, Lan, Shao, Hu, Xue and Liu</copyright-statement>
<copyright-year>2024</copyright-year>
<copyright-holder>Yang, Gou, Lan, Shao, Hu, Xue and Liu</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>Tislelizumab, a humanized IgG4 anti-PD-1 monoclonal antibody has been approved in China and Europe. According to the published clinical research, tislelizumab shows satisfactory safety profile. No severe hepatotoxicity or acute kidney injury were reported.</p>
</sec>
<sec>
<title>Case presentation</title>
<p>We presented a case study of a 74-year-old man who developed acute kidney injury (grade 3) and acute liver injury (grade 4) after being administered tislelizumab for the treatment of esophageal squamous cell carcinoma. We reviewed the patient&#x2019;s history, physical examination, and laboratory findings and provided comprehensive differentials of the possible causes of the toxicities. Immune Checkpoint Inhibitors (ICI) hepatotoxicity and nephrotoxicity were confirmed clinically. We also discussed the management of toxicities associated with ICIs and the need for a multidisciplinary approach to care.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>The case highlights the importance of close monitoring and prompt management of toxicities associated with ICIs and the need for further research to better understand the risk factors for these toxicities and to identify effective treatments for them.</p>
</sec>
</abstract>
<kwd-group>
<kwd>tislelizumab</kwd>
<kwd>acute kidney injury</kwd>
<kwd>acute liver injury</kwd>
<kwd>immune checkpoint inhibitor</kwd>
<kwd>esophageal squamous cell carcinoma</kwd>
</kwd-group>
<counts>
<fig-count count="1"/>
<table-count count="1"/>
<equation-count count="0"/>
<ref-count count="26"/>
<page-count count="6"/>
<word-count count="2240"/>
</counts>
<custom-meta-wrap>
<custom-meta>
<meta-name>section-in-acceptance</meta-name>
<meta-value>Gastrointestinal Cancers: Gastric and Esophageal Cancers</meta-value>
</custom-meta>
</custom-meta-wrap>
</article-meta>
</front>
<body>
<sec id="s1" sec-type="intro">
<title>Introduction</title>
<p>Esophageal squamous cell carcinoma (ESCC) is a type of cancer derived from the epithelial cells of the esophagus. It is one of the most common types of cancer globally with a high mortality rate. According to the Global Cancer Observatory, there were approximately 500,000 new cases of ESCC reported globally in 2020. The incidence of ESCC has also been shown to vary across different regions, with the highest rates found in eastern to central Asia, along the rift valley in east Africa (<xref ref-type="bibr" rid="B1">1</xref>).</p>
<p>The current treatment options of ESCC includes surgery, chemotherapy, radiotherapy, and immunotherapy. These treatments are used depending on the stage of the cancer, the patient&#x2019;s general health, and the preference of the patient and their doctor. For the advanced and metastatic ESCC, the goals of therapy are to palliate symptoms and improve survival and immunotherapy plays an active role. For advanced or metastatic ESCC patients, the use of pembrolizumab and nivolumab are related to a significant survival benefit. Even higher level of evidence suggested the use of PD-1 inhibitors for patients with certain MSI profile and PD-L1 testing results (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B3">3</xref>).</p>
<p>Tislelizumab, a humanized IgG4 anti-PD-1 monoclonal antibody produced by BeiGene, Inc. has been approved in China and Europe for ESCC but has not been approved by US FDA. According to the published clinical research, tislelizumab shows beneficial overall survival and satisfactory safety profile in the ESCC population (<xref ref-type="bibr" rid="B4">4</xref>&#x2013;<xref ref-type="bibr" rid="B7">7</xref>). The most common grade 3 or 4 treatment-related adverse events were decreased neutrophil/WBC count and anemia. The product information of tislelizumab in Europe revealed that immune-related nephritis and renal dysfunction (greater than grade 2) happened in 0.4% of patient using tislelizumab monotherapy, the median time from first dose to renal adverse events was 1.2 months. 50% of the renal injury recovered in 3 days to 16.2 months (<xref ref-type="bibr" rid="B8">8</xref>). No severe hepatotoxicity or acute kidney injury (AKI) was reported in the clinical trials (<xref ref-type="bibr" rid="B4">4</xref>&#x2013;<xref ref-type="bibr" rid="B7">7</xref>). Herein, we report a case who has been administrated tislelizumab and developed severe dual organ dysfunction (kidney and liver). Written informed consent for this study was obtained from the patient himself.</p>
</sec>
<sec id="s2">
<title>Case presentation</title>
<p>On Aug. 8<sup>th</sup>, 2023, a 74-year-old Asian man presented to the local oncology center due to dysphagia and underwent esophageal endoscopy. Biopsies taken during the scope revealed ESCC in the mid-esophagus. The patient has no comorbidities and no long-term treatments. The following evaluation including Positron emission tomography&#x2013;computed tomography (PET-CT) suggested the stage of cTxN2M0. The oncology center recommended neoadjuvant therapy, which consisted of tislelizumab 200 mg on day 1 + albumin-bound paclitaxel 156 mg on days 1, 8, and 15 + carboplatin 400 mg on day 1. The patient completed the first cycle of therapy (day 1: Aug. 23<sup>rd</sup>, 2023). After the rescue of thrombocytopenia, it was scheduled to start the second cycle on Sept. 20<sup>th</sup>. However, on arrival at the clinic on Sept. 20<sup>th</sup>, the patient was found to have slightly elevated liver enzymes (Alanine transaminase (ALT) 89 U/L (reference range 7-40 U/L), Aspartate Aminotransferase (AST) 68 U/L (reference range 13-35 U/L)), with total bilirubin at 136.11 &#xb5;mol/L (reference range 3.4-17.1 &#xb5;mol/L), Direct bilirubin (DBIL) at 90.6 &#xb5;mol/L (reference range 0-5 &#xb5;mol/L), Serum creatinine (SCr) at 304 &#xb5;mol/L (reference range 41-81 &#xb5;mol/L), and Blood urea nitrogen (BUN) at 19.2 mmol/L (reference range 3.1-8.9) (<xref ref-type="table" rid="T1">
<bold>Table&#xa0;1</bold>
</xref>). The patient also had jaundiced skin and sclera. The patient reported no abdominal pain, bloating, diarrhea, vomiting, oliguria, skin rashes, joint pain, or photosensitivity. The patient also reported that in the past 3-4 days, the stool had been light-colored. Then the patient was referred to the nephrologist in Naval Medical Center of PLA. The latest biochemistry results (Sept. 9<sup>th</sup>) were also provided. Physical examination was unremarkable other than jaundice. The patient was diagnosed with AKI stage 3 and acute liver injury and was hospitalized. The following examinations including abdominal ultrasound, renal vascular ultrasound, urine routine test, blood lipid profile, Magnetic resonance cholangiopancreatography (MRCP), and viral hepatitis screening were ordered to figure out the causes of renal and liver injury. The results suggested generally normal blood routine tests and urine routine tests (except for positive urinary bilirubin). No evidence of glomerular diseases, pre-/post-renal diseases was detected according to the clinical features, normal urine routine test, urinary system and renal vascular ultrasound examination. Acute tubulointerstitial disease was suspected. The most possible reason would be nephrotoxic exposure. In terms of liver injury, liver enzyme tests suggested cholestatic pattern abnormality (R&lt;2) [(ALT/Upper limit of normal ALT)/(Alkaline phosphatase/Upper limit of normal Alkaline phosphatase)] (<xref ref-type="bibr" rid="B9">9</xref>). No evidence of extrahepatic cholestasis was found through ultrasound and MRCP. Viral hepatitis screening results were all negative. Drug-related intrahepatic cholestasis was suspected.</p>
<table-wrap id="T1" position="float">
<label>Table&#xa0;1</label>
<caption>
<p>Lab test results provided on Sept. 20<sup>th</sup>.</p>
</caption>
<table frame="hsides">
<thead>
<tr>
<th valign="middle" align="left"/>
<th valign="middle" align="left">Hb (g/L)</th>
<th valign="middle" align="left">PLT (*10^9/L)</th>
<th valign="middle" align="left">WBC (*10^9/L)</th>
<th valign="middle" align="left">ALT (U/L)</th>
<th valign="middle" align="left">AST (U/L)</th>
<th valign="middle" align="left">ALP (U/L)</th>
<th valign="middle" align="left">GGT (U/L)</th>
<th valign="middle" align="left">TB (umol/L)</th>
<th valign="middle" align="left">DBIL (umol/L)</th>
<th valign="middle" align="left">SCr (umol/L)</th>
<th valign="middle" align="left">BUN (mmol/L)</th>
<th valign="middle" align="left">alb (g/L)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="middle" align="left"/>
<td valign="middle" align="left">115-150</td>
<td valign="middle" align="left">125-350</td>
<td valign="middle" align="left">3.69-9.16</td>
<td valign="middle" align="left">7-40</td>
<td valign="middle" align="left">13-35</td>
<td valign="middle" align="left">50-135</td>
<td valign="middle" align="left">7-40</td>
<td valign="middle" align="left">3.4-17.1</td>
<td valign="middle" align="left">0-5</td>
<td valign="middle" align="left">41-81</td>
<td valign="middle" align="left">3.1-8.9</td>
<td valign="middle" align="left">40-55</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-08-16</bold>
</td>
<td valign="middle" align="left">134</td>
<td valign="middle" align="left">101</td>
<td valign="middle" align="left">4.9</td>
<td valign="middle" align="left">20</td>
<td valign="middle" align="left">31</td>
<td valign="middle" align="left">92</td>
<td valign="middle" align="left">32</td>
<td valign="middle" align="left">10.5</td>
<td valign="middle" align="left">2.1</td>
<td valign="middle" align="left">83</td>
<td valign="middle" align="left">6</td>
<td valign="middle" align="left">40</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-08-25</bold>
</td>
<td valign="middle" align="left">119</td>
<td valign="middle" align="left">97</td>
<td valign="middle" align="left">5.7</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-01</bold>
</td>
<td valign="middle" align="left">106</td>
<td valign="middle" align="left">98</td>
<td valign="middle" align="left">3.2</td>
<td valign="middle" align="left">28</td>
<td valign="middle" align="left">30</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">13.1</td>
<td valign="middle" align="left">3.2</td>
<td valign="middle" align="left">98</td>
<td valign="middle" align="left">7.1</td>
<td valign="middle" align="left">37</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-04</bold>
</td>
<td valign="middle" align="left">109</td>
<td valign="middle" align="left">101</td>
<td valign="middle" align="left">1.62</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-09</bold>
</td>
<td valign="middle" align="left">117</td>
<td valign="middle" align="left">72</td>
<td valign="middle" align="left">3.3</td>
<td valign="middle" align="left">25</td>
<td valign="middle" align="left">28</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">10.4</td>
<td valign="middle" align="left">2.4</td>
<td valign="middle" align="left">92</td>
<td valign="middle" align="left">9.1</td>
<td valign="middle" align="left">40</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-11</bold>
</td>
<td valign="middle" align="left">107</td>
<td valign="middle" align="left">62</td>
<td valign="middle" align="left">2.7</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-14</bold>
</td>
<td valign="middle" align="left">113</td>
<td valign="middle" align="left">70</td>
<td valign="middle" align="left">7.7</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-15</bold>
</td>
<td valign="middle" align="left">106</td>
<td valign="middle" align="left">69</td>
<td valign="middle" align="left">7.7</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-18</bold>
</td>
<td valign="middle" align="left">102</td>
<td valign="middle" align="left">78</td>
<td valign="middle" align="left">6.9</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
</tr>
<tr>
<td valign="middle" align="left">
<bold>2023-09-20</bold>
</td>
<td valign="middle" align="left">102</td>
<td valign="middle" align="left">120</td>
<td valign="middle" align="left">6.8</td>
<td valign="middle" align="left">89</td>
<td valign="middle" align="left">68</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">/</td>
<td valign="middle" align="left">136.1</td>
<td valign="middle" align="left">90.6</td>
<td valign="middle" align="left">304</td>
<td valign="middle" align="left">19.2</td>
<td valign="middle" align="left">31</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn>
<p>Hb, hemoglobin; PLT, platelet count; WBC, white blood cell count; ALT, alanine transaminase, AST, aspartate aminotransferase, ALP, alkaline phosphatase; GGT, gamma-glutamyl Transferase; TB, Total bilirubin; DB, Direct bilirubin; SCr, serum creatinine; BUN, Blood Urea Nitrogen; alb, albumin. * to multiply; / no data.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<p>Then we reviewed the history of immunotherapy and chemotherapy. Four weeks before the onset of kidney and liver injury, the patient was administrated tislelizumab, carboplatin, and albumin-bound paclitaxel. Two more doses of albumin-bound paclitaxel were administrated in the following two weeks. No other medications or herb supplements were taken. Nephrotoxicity of platinum agents is well established while AKI from platinum typically manifests with a rise of SCr after three to seven days of exposure (<xref ref-type="bibr" rid="B10">10</xref>&#x2013;<xref ref-type="bibr" rid="B12">12</xref>). Carboplatin is significantly less nephrotoxic than cisplatin (<xref ref-type="bibr" rid="B13">13</xref>, <xref ref-type="bibr" rid="B14">14</xref>). Paclitaxel undergoes minimal renal excretion. It is usually safe for the kidneys. Limited data on animals showed acute (24-48h) renal toxicity (<xref ref-type="bibr" rid="B15">15</xref>). It is unlikely for the patient to experience acute renal dysfunction after weeks of platinum/Paclitaxel administration. It should be noted that tislelizumab falls under the category of immune checkpoint inhibitors (ICIs), which allows us to draw some inferences regarding its potential side effects. After excluding other causes of abnormal liver/renal tests, ICI hepatotoxicity and nephrotoxicity were confirmed clinically. According to the guideline on ICI adverse events management (<xref ref-type="bibr" rid="B16">16</xref>), we gave methylprednisolone 48 mg qd from Sept. 27<sup>th</sup>. Basic metabolic panels were monitored closely. After 7-day treatment, renal function was restored somewhat, while there was no improvement in liver enzymes and bilirubin (<xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>). Dual plasma molecular adsorption system was applied four times from Oct. 3<sup>rd</sup>. Mycophenolate mofetil 0.5g bid was also started to treat the refractory hepatotoxicity. On Oct. 7<sup>th</sup>, the patient was referred to a hepatologist with expertise in ICI hepatitis. Phone call follow-ups were conducted regularly after that. In the following days, basic metabolic panels were also showed in <xref ref-type="fig" rid="f1">
<bold>Figure&#xa0;1</bold>
</xref>. Mycophenolate mofetil was discontinued at Oct. 23 while methylprednisolone was still keep going. At Nov 1<sup>st</sup>, the patient developed signs of hospital-acquired pneumonia. Invasive gillosis was confirmed based on the chest imaging and airway specimen. The patient did not respond to the antifungals and died at Nov. 5<sup>th</sup>.</p>
<fig id="f1" position="float">
<label>Figure&#xa0;1</label>
<caption>
<p>Follow-up of the major lab test results over time. ALT, alanine transaminase (reference range 7-40 U/L), AST, aspartate aminotransferase (reference range 13-35 U/L), ALP: alkaline phosphatase (reference range 50-135 U/L); GGT, gamma-glutamyl Transferase (reference range 7-40 U/L); TB, Total bilirubin (reference range 3.4-17.1 umol/L); DB, Direct bilirubin (reference range 0-5 umol/L); SCr, serum creatinine (reference range 41-81 umol/L); BUN, Blood Urea Nitrogen (reference range 3.1-8.9 mmol/L); PT, prothrombin time (reference range 9-13s).</p>
</caption>
<graphic mimetype="image" mime-subtype="tiff" xlink:href="fonc-14-1347896-g001.tif"/>
</fig>
</sec>
<sec id="s3" sec-type="discussion">
<title>Discussion</title>
<p>ICIs have been a paradigm shift in the treatment of many types of cancer. These drugs work by blocking the receptors on T cells that keep the immune system from attacking the cancer cells (<xref ref-type="bibr" rid="B17">17</xref>). This has resulted in significant improvements in the prognosis of many cancer patients, particularly those with metastatic or advanced disease (<xref ref-type="bibr" rid="B18">18</xref>). Several ICIs have been approved by the FDA for the treatment of multiple types of cancer. However, despite these promising results, ICIs can also cause a range of side effects, including autoimmune disorders and gastrointestinal side effects. These toxicities can be managed with the use of corticosteroids, immune modulators, and supportive care (<xref ref-type="bibr" rid="B19">19</xref>).</p>
<p>Toxicities associated with tislelizumab are known to occur, due to the nature of ICIs. However, the incidence and severity of these toxicities may vary between individuals. In the case of the patient we reported, the patient experienced severe dual-organ toxicities, including AKI (grade 3) and acute liver toxicity (grade 4), which have not been previously reported in association with tislelizumab. This case highlighted the importance of close monitoring and prompt management of toxicities associated with ICIs, particularly when using a new drug or in combination with other therapies. In clinical practice, patients often use a variety of medications and herb supplements, which can result in complex medication interactions. Those confounding factors lead to delayed diagnosis of ICI adverse events and potentially even requiring a biopsy to accurately determine the source of the adverse reaction. It also underscored the need for further research to better understand the mechanisms, risk factors for these toxicities and to identify effective treatments for them.</p>
<p>The renal outcome of the toxicities due to ICIs is not well studied. While the management of toxicities associated with ICIs has been well-established, the management of renal complications is not fully evidence-based. In other words, while there are guidelines and protocols for managing these toxicities, the evidence for these approaches is lacking. Besides, kidney histopathology is heterogeneous due to ICI toxicity (<xref ref-type="bibr" rid="B20">20</xref>). Glomerular capillaries, mesangial matrix/cells, podocytes and tubule could be possible target of activated immune cells (<xref ref-type="bibr" rid="B21">21</xref>&#x2013;<xref ref-type="bibr" rid="B24">24</xref>). More clinical studies are needed in this field to improve our understanding of the renal outcome and to provide evidence-based treatments for these complications. It is important to note that the management of renal complications due to ICIs can be challenging, and a collaborative approach between nephrologists and oncologists is essential for achieving the best possible outcomes for patients. In addition, close monitoring and prompt management of toxicities associated with ICIs will remain critical for ensuring their safe and effective use in the treatment of cancer.</p>
<p>The risk factors associated with experiencing renal/liver injury due to ICI use are not yet entirely clear. While there is some evidence suggesting that certain factors, such as type/dose of ICIs and underlying malignancy, may increase the risk (<xref ref-type="bibr" rid="B25">25</xref>, <xref ref-type="bibr" rid="B26">26</xref>), more research is needed to fully understand the risk factors. This is particularly important given the growing use of ICIs in the treatment of cancer patients. As more information becomes available about the risks associated with ICI use, it is important for healthcare providers to carefully consider these risks when prescribing ICIs to patients. Healthcare providers should also be familiar with the signs and symptoms of renal/liver injury and should monitor patients closely for these toxicities. The management of toxicities associated with ICI use requires a multidisciplinary approach.</p>
<p>In summary, more research is needed to fully understand the risk factors for renal/liver injury associated with ICI use, and healthcare providers should carefully weigh the benefits and risks of ICI use in cancer treatment, while also being prepared to manage any toxicities that may arise.</p>
</sec>
<sec id="s4" sec-type="data-availability">
<title>Data availability statement</title>
<p>The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding authors.</p>
</sec>
<sec id="s5" sec-type="ethics-statement">
<title>Ethics statement</title>
<p>The studies involving humans were approved by Institutional Review Committee of the Naval Medical Center. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants&#x2019; legal guardians/next of kin. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="s6" sec-type="author-contributions">
<title>Author contributions</title>
<p>BY: Funding acquisition, Writing &#x2013; original draft, Writing &#x2013; review &amp; editing, Data curation. WG: Writing &#x2013; review &amp; editing, Data curation, Investigation. NYL: Data curation, Investigation, Writing &#x2013; review &amp; editing. QS: Data curation, Investigation, Writing &#x2013; review &amp; editing. WH: Data curation, Investigation, Writing &#x2013; review &amp; editing. CX: Writing &#x2013; review &amp; editing, Writing &#x2013; original draft. NML: Conceptualization, Writing &#x2013; review &amp; editing.</p>
</sec>
</body>
<back>
<sec id="s7" sec-type="funding-information">
<title>Funding</title>
<p>The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The project was funded by Naval medical center of PLA (21TPQN3201, 21M3201, 21M3202, 24X3201). The funder has no impact on patients care, treatment decision making and data abstraction.</p>
</sec>
<sec id="s8" sec-type="COI-statement">
<title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s9" sec-type="disclaimer">
<title>Publisher&#x2019;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
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