AUTHOR=Luo Baofa , Gao Wei , Li Ting , Yu Xinran , Guo Fei TITLE=Primary Ewing’s sarcoma of the intestine: case report and literature review JOURNAL=Frontiers in Oncology VOLUME=Volume 14 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1357945 DOI=10.3389/fonc.2024.1357945 ISSN=2234-943X ABSTRACT=Ewing sarcoma (ES) / peripheral primitive neuroectodermal tumor (PNET) is a highly aggressive malignant tumor that typically presents in bone and soft tissue. Primary ES of the intestine is relatively rare, which poses a challenge in distinguishing it from other primary tumors of the small intestine through imaging. This article details a case study of Ewing sarcoma originating in the intestine. Computed tomography imaging suggested a small intestinal stromal tumor (SIST), and so the patient underwent resection of the small bowel and omental tumor. Pathology results confirmed the diagnosis of Ewing sarcoma of the small intestine. Following surgery, the patient underwent 6 cycles of chemotherapy, and a follow-up PET-CT revealed widespread dissemination of the disease with intraperitoneal metastasis, ultimately resulting in the death of the patient.