AUTHOR=Xing Xiaoke , Que Xiangyong , Zheng Sihao , Wang Shuxian , Song Qibin , Yao Yi , Zhang Pingfeng 

TITLE=Emerging roles of FOXK2 in cancers and metabolic disorders

JOURNAL=Frontiers in Oncology

VOLUME=14

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1376496

DOI=10.3389/fonc.2024.1376496

ISSN=2234-943X

ABSTRACT=<p>FOXK2, a member of the Forkhead box K (FOXK) transcription factor family, is widely expressed in various tissues and organs throughout the body. FOXK2 plays crucial roles in cell proliferation, differentiation, autophagy, <italic>de novo</italic> nucleotide biosynthesis, DNA damage response, and aerobic glycolysis. Although FOXK2 is recognized as an oncogene in colorectal cancer and hepatocellular carcinoma, it acts as a tumor suppressor in breast cancer, cervical cancer, and non-small cell lung cancer (NSCLC). This review provides an overview of the recent progress in understanding the regulatory mechanisms of FOXK2 and its downstream targets, highlights the significant impact of FOXK2 dysregulation on cancer etiology, and discusses the potential of targeting FOXK2 for cancer treatment.</p>