AUTHOR=Xue Song , Chen Jia-qi , Wang Tong , Zhang Li-na , Chen Man , Sun Hui-peng 

TITLE=Case report: NUP98::LEDGF fusion gene drives malignant hematological tumor with mixed immunological phenotype

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1396655

DOI=10.3389/fonc.2024.1396655

ISSN=2234-943X

ABSTRACT=This is the first report of NUP98::LEDGF positive malignant hematological tumor expressing T cell and myeloid lineage antigens. Patients carrying this fusion gene have a high relapse rate and a poor prognosis, allo-HSCT may be an option to cure this disease. This patient underwent allo-HSCT, a relapse occurred three months post-transplantation. Subsequent screening at our hospital confirmed the presence of the NUP98::LEDGF fusion gene, salvage therapy was administered, followed by a successful second allo-HSCT. Furthermore, we included eight previously reported cases from the literature for analysis and discuss.