AUTHOR=Huang Yan-Ying , Zhang Yue , Xie Wen-Jun 

TITLE=Case report: Germline BRCA 2 mutation in primary peritoneal carcinoma: a rare malignancy

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1428918

DOI=10.3389/fonc.2024.1428918

ISSN=2234-943X

ABSTRACT=BackgroundPrimary peritoneal carcinoma (PPC) is a rare malignancy. Clinically, its histological morphology resembles that of epithelial ovarian tumors (EOC), often leading to misdiagnosis. Diagnosis and treatment of PPC are time-sensitive because of the rapidly progressive nature of the disease.Case reportHerein, we report the case of a 54-year-old woman who was initially diagnosed with ovarian cancer; however, extensive workup showed evidence of Müllerian PPC origin. Furthermore, the patient harbored a targetable BRCA mutation.ConclusionThe patient was treated with the BRCA-targeting agents and had a good prognosis after surgery.