AUTHOR=Du Juan , Luo Hui , Ye Shuang , Zhang Hui , Zheng Zhen , Liu Kaitai 

TITLE=Unraveling IFI44L’s biofunction in human disease

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1436576

DOI=10.3389/fonc.2024.1436576

ISSN=2234-943X

ABSTRACT=Interferon-induced protein 44-like (IFI44L) is regarded as an immune-related gene and is a member of interferon-stimulated genes (ISGs). They participate in network transduction, and its own epigenetic modifications, apoptosis, cell-matrix formation, and many other pathways in tumors, autoimmune diseases, and viral infections. The current review provides a comprehensive overview of the onset and biological mechanisms of IFI44L and its potential clinical applications in malignant tumors and non-neoplastic diseases.