AUTHOR=von Arx Claudia , Calderaio Claudia , Calabrese Alessandra , Marciano Benedetta , Martinelli Claudia , Di Lauro Vincenzo , Cerillo Ivana , Cianniello Daniela , De Laurentiis Michelino 

TITLE=The multidisciplinary management of HER2-positive breast cancer brain metastases: from new biological insights to future therapeutic options

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1447508

DOI=10.3389/fonc.2024.1447508

ISSN=2234-943X

ABSTRACT=The advent and success of new drugs for treating HER2-positive metastatic breast cancer has led to a constant improvement in disease and progression-free survival as well as overall survival. Despite these advantages, the overall survival and quality of life of patients with HER2-positive breast cancer brain metastases are significantly worse than the ones of patients with HER2-positive breast cancer metastases outside the brain. For this reason, prevention and treatment of brain metastasis remain a major clinical challenge and the keys to further improving the clinical and survival outcomes of HER2-positive breast cancer patients. This review discusses the etiopathogenesis of brain metastasis, the currently available treatments, and the future perspective on new treatment strategies and diagnostic tools.