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PERSPECTIVE article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 14 - 2024 |
doi: 10.3389/fonc.2024.1456658
This article is part of the Research Topic Unveiling the Next Generation of Cancer Immunity & Immunotherapy View all articles
Intratumoral Injection and Retention Hold Promise to Improve Cytokine Therapies for Cancer
Provisionally accepted- Immunology and Microbial Science, Cullinan Oncology, Cambridge, CA, United States
As powerful activators of the immune system, cytokines have been extensively explored for treating various cancers. But despite encouraging advances and some drug approvals, the broad adoption of cytokine therapies in the clinic has been limited by low response rates and sometimes severe toxicities. This in part reflects an inefficient biodistribution to tumors or a pleiotropic action on bystander cells and tissues. Here, we first review these issues and then argue for the intratumoral delivery of engineered cytokine fusion proteins that have been optimized for tumor retention as a potential solution to overcome these limitations and realize the potential of cytokines as highly effective therapeutics for cancer.
Keywords: cytokine, Intratumoral, IL-2, il-12, Collagen, CLN-617, Immunotherapy, Cancer
Received: 28 Jun 2024; Accepted: 02 Aug 2024.
Copyright: © 2024 Sauer, Rakhra, Wu, Mehta, Michaelson and Baeuerle. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Karsten Sauer, Immunology and Microbial Science, Cullinan Oncology, Cambridge, 92037, CA, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Kavya Rakhra