AUTHOR=Negrut Roxana Loriana , Cote Adrian , Tica Ovidiu , Maghiar Adrian Marius TITLE=Case report: A rare case of three synchronous colon tumors with metastasis to the left inguinal lymph node JOURNAL=Frontiers in Oncology VOLUME=Volume 14 - 2024 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1459620 DOI=10.3389/fonc.2024.1459620 ISSN=2234-943X ABSTRACT=This study presents a rare case of three synchronous colon tumors with metastasis to the left inguinal lymph node, challenging the conventional understanding of the metastatic pathways and highlighting the exceptional nature of such occurrences. This highlights the importance of considering alternative atypical metastatic routes for the management of colon cancer. A literature search was performed to identify similar cases. Our findings emphasize the need for broader diagnostic evaluations to detect atypical metastasis at early stages. Furthermore, this case highlights the need for potential refinements in follow-up and screening protocols to capture unusual patterns of cancer spread. This case encourages further research into innovative treatments tailored to the unique metastatic behaviors observed in synchronous colon tumors, with a view to improving outcomes in similar cases.