AUTHOR=Xiao Pingping , Dong Zhigao , Wang Qingqing , Su Junnan , Chen Yongquan , Lin Yiwan 

TITLE=Case report: Successful use of ruxolitinib to treat interstitial pneumonia as an unusual primary presentation in primary myelofibrosis—two birds with one stone

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1475036

DOI=10.3389/fonc.2024.1475036

ISSN=2234-943X

ABSTRACT=BackgroundInterstitial lung disease (ILD) is a rare clinical presentation of primary myelofibrosis (PMF).Case presentationWe report a case of ILD as the main manifestation on admission. A 58-year-old man was diagnosed with PMF owing to worsening anemia following treatment failure for conventional interstitial pneumonia.ResultsAnemia and interstitial pneumonia both significantly improved following treatment with a Janus kinase 2 gene inhibitor. In this report, we discuss the possible mechanisms underlying PMF complicated with ILD.