AUTHOR=Liu Hongliang , Wang Xi , Liu Lingyan , Yan Bingsong , Qiu Fabo , Zhou Bin 

TITLE=Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1484027

DOI=10.3389/fonc.2024.1484027

ISSN=2234-943X

ABSTRACT=In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field.