AUTHOR=Zheng Shicheng , Lin Zhongqiao , Zhang Ruibo , Cheng Zihang , Li Kaixin , Gu Chenkai , Chen Yu , Lin Jing 

TITLE=Progress in immunotherapy for brain metastatic melanoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1485532

DOI=10.3389/fonc.2024.1485532

ISSN=2234-943X

ABSTRACT=Melanoma is highly aggressive, with brain metastasis being a significant contributor to poor outcomes. Immunotherapy has emerged as a crucial treatment modality for melanoma, particularly for addressing brain metastases. This review explores recent developments in immunotherapy for patients with melanoma brain metastasis, with such treatments encompassing immune checkpoint inhibitors and various immunotherapy combination approaches, such as dual immunotherapy, immunotherapy combined with chemotherapy, immunotherapy combined with targeted drugs, and immunotherapy combined with radiotherapy. This article also discusses existing treatment obstacles and potential future avenues for research and clinical practice.