AUTHOR=Sheikh Shehryar R. , Klesse Laura J. , Mangum Ross , Bui Ashley , Siegel Benjamin I. , Abdelbaki Mohamed S. , Patel Neha J. 

TITLE=The role of MEK inhibition in pediatric low-grade gliomas

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1503894

DOI=10.3389/fonc.2024.1503894

ISSN=2234-943X

ABSTRACT=Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in children. Many patients with unresectable tumors experience recurrence or long-term sequelae from standard chemotherapeutics. This mini-review explores the emerging role of MEK inhibitors in the management of pLGGs, highlighting their potential to transform current treatment paradigms. We review the molecular basis for therapeutic MEK inhibition in the context of pLGG, provide an evidence base for the use of the major MEK inhibitors currently available in the market for pLGG, and review the challenges in the use of MEKi inhibitors in this population.