AUTHOR=Lu Evelyn Ruoyun , Yeung Wai Lan , Yau Jeffrey Ping Wa , Chu King Sun , Kan Elaine Yee Ling , Chiang Alan Kwok Shing 

TITLE=Case Report: Neurolymphomatosis of the peripheral nerve as a presentation of relapsed pediatric high-grade B cell lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1477848

DOI=10.3389/fonc.2025.1477848

ISSN=2234-943X

ABSTRACT=Neurolymphomatosis (NL) of the peripheral nerve in pediatrics has never been reported, and ultrasonography (USG) as an investigation modality is rarely used. We report a case of an 11-year-old boy with stage 4 mature high-grade B cell lymphoma who presented with a two-week history of right ulnar neuropathy and left sciatic neuropathy one month after the completion of frontline chemotherapy. This case report illustrates the rare presentation of NL in lymphoma relapse and hopes to emphasize how early identification of this diagnosis and timely treatment are essential. Moreover, this case points out how USG, in the context of palpable mass and localized neurological signs, could facilitate a diagnosis of NL.