AUTHOR=Li Zhihua , Chu Jian , Shen Wennan , Chen Junnan , Dong Yuemei , Zhang Manze , Zhao Nan , Zhao Wei , Zha Haoran , Wang Ning , Han Yalin , Li Zhaoxia TITLE=A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review JOURNAL=Frontiers in Oncology VOLUME=Volume 15 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1484383 DOI=10.3389/fonc.2025.1484383 ISSN=2234-943X ABSTRACT=Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF). We reviewed the literature and evaluated survival benefits in patients with LM harboring BRAF non-V600E mutations treated with CSF chemotherapy and mitogen-activated extracellular signal-regulated kinase inhibitors.