AUTHOR=Saeed Wizra 

TITLE=The relationship of depression and quality of life with mediating role of death anxiety, silver lining and religious coping among women cancer patients in Pakistan

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1489169

DOI=10.3389/fonc.2025.1489169

ISSN=2234-943X

ABSTRACT=ObjectivePakistani women are among those most likely to be diagnosed with cancer. Cancer patients experience significant changes that impact their mental and physical health, primarily due to the increased burden of the disease. This study aims to explore the relationship between depression and quality of life (QOL) in cancer patients, as well as how religious coping (RC), silver lining (SL), and death anxiety (DA) influence this connection.Materials and methodsA total of 450 individuals diagnosed with cancer were recruited from outpatient departments of various hospitals in Islamabad. Out of these, 421 patients who met the inclusion criteria were included in the study. Three types of cancer were considered for data collection there was 132 (31.4%) breast cancer, 154 (36.6%) blood cancer and 135 (32.1%) lung cancer patients Participants were assessed using the following measurement tools: the Demographic Form, The Short Muslim Religious Practice and Religious Belief, the Patient Health Questionnaire (PHQ-9, 2011), the Death Anxiety Scale, the Silver Lining Questionnaire, and the WHOQOL-BREF Questionnaire.ResultsThe findings of the current study revealed a negative association between depression and quality of life (QOL). Additionally, death anxiety (DA) was positively correlated with both depression and QOL. Conversely, silver lining (SL) and religious coping (RC) were negatively associated with depression and positively associated with QOL. Path analysis indicated that DA, SL, and RC served as mediators in the relationship between depression and QOL among cancer patients.ConclusionThe study concluded that cancer patients can better manage their depression and enhance their quality of life by strengthening their silver lining (SL) and religious coping (RC). These findings should be considered when developing strategies to manage depression and other psychological issues in cancer patients, thereby providing more effective treatments for this population