AUTHOR=Xiao Liming , Zhao Ziyi , Zhou Li , Yan Jiao , Luo Danling , Liu Fucen , Zhou Qiaolin , Huang Dan 

TITLE=Clinical and imaging features of primary thyroid MALT lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1498609

DOI=10.3389/fonc.2025.1498609

ISSN=2234-943X

ABSTRACT=Primary thyroid lymphoma is a rare hematologic malignancy of the thyroid gland, accounting for approximately 5% of all malignant thyroid tumors. The most common pathological type is B-cell-derived non-Hodgkin’s lymphoma, mainly diffuse large B-cell lymphoma, followed by mucosa-associated lymphoid tissue lymphoma and mixed types. The clinical and radiographic characteristics of primary thyroid lymphoma are non-specific, often leading to misdiagnosis as thyroiditis and a delay in treatment. A 60-year-old woman was referred to our hospital with neck swelling that had persisted for a week. Histopathological findings of a thyroid biopsy revealed mucosa-associated lymphoid tissue lymphoma. Bone marrow examination revealed atypical lymphocytes on myelograms. [18F]FDG PET/CT images showed increased [18F]FDG uptake in both lobes of the thyroid gland and the cervical lymph nodes. The patient was diagnosed with stage IV primary thyroid mucosa-associated lymphoid tissue lymphoma. The patient subsequently received four cycles of R-CEOP chemotherapy and remained under follow-up. Due to the rarity of this case, we conducted a systematic literature review to better understand the disease and improve timely diagnosis and treatment.