AUTHOR=Yousefi Mohammad Hasan , Masoudi Alireza , Saberi Rounkian Masoumeh , Mansouri Maryam , Hojat Bita , Kaveh Samani Marzieh , Veisi Razieh , Honarvar Bakeshloo Parisa , Nosratipour Reza , Afkhami Hamed , Saeb Sepideh 

TITLE=An overview of the current evidences on the role of iron in colorectal cancer: a review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1499094

DOI=10.3389/fonc.2025.1499094

ISSN=2234-943X

ABSTRACT=Colorectal cancer (CRC) is a common and lethal malignancy that affects millions of people worldwide. Iron is an essential micronutrient that plays a vital role in various biological processes, but also has pro-oxidant and pro-inflammatory effects that may contribute to carcinogenesis. The relationship between iron and CRC is complex and influenced by multiple factors, such as dietary intake, absorption, storage, metabolism, and excretion of iron, as well as genetic and environmental factors that modulate iron homeostasis. This review article aims to provide an overview of the current evidences on the role of iron in CRC, discussing the potential mechanisms by which iron may affect CRC development and progression, as well as the implications for prevention and treatment. This review tries to focus on the following aspects: an introduction to iron and its role in CRC, role of heme and non-heme iron in CRC, dietary patterns, nutrition, and CRC, iron overload in CRC, iron deficiency and its role in CRC especially in surgery outcome and iron therapy and blood transfusion in CRC.