AUTHOR=Li Lingyi , Luo Man 

TITLE=Exploration in association between vitamin D and cutaneous melanoma and explainable machine learning prediction

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1503611

DOI=10.3389/fonc.2025.1503611

ISSN=2234-943X

ABSTRACT=ObjectiveThis study aims to examine association between vitamin D with melanoma and develop an explainable machine learning model.MethodsFor this study, relevant data were downloaded from the CDC’s National Health and Nutrition Examination Survey (NHANES) program, for the three survey cycles 2011-2012, 2013–2014 and 2015-2016. Self-reported melanoma data, serum vitamin D levels, and other covariates were downloaded and analyzed. Analysis of variance in this study was performed using t-tests and chi-square tests, modelling was performed using logistic regression based on NHANES weights, and other risk factors were analyzed using forest plots. Ten machine learning models were compared and XGboost was selected for the melanoma prediction.ResultsIn this study, logistic regression analysis revealed a protective effect of higher vitamin D levels in melanoma, the ORs were much less than 1 for Q2 (OR=0.97, 95% CI (0.44, 0.98)), Q3 (OR=0.71, 95% CI (0.65, 0.92)), and Q4 (OR=0.32, 95% CI (0.55, 0.81)). Meanwhile, forest plot analysis showed that vitamin D, the number of sunburns in the past year, advanced age, Caucasian, education some college, single and unmarried, smoking, diabetes and hypertension, were all statistically significant. The OR was higher in men than in women, with Q4 values of 0.31 (95% CI: 0.18–0.51) for men and 0.29 (95% CI: 0.15–0.45) for women. OR was higher in the senior patients than in the non-senior group, with Q4 (OR=0.53, 95% CI (0.23, 0.73)). An explainable XGBoost model had AUC 0.906, and in the model vitamin D had main contribution to the model.ConclusionIn conclusion, this study concluded that vitamin D decreases melanoma risk based on a larger sample and multi-covariate analysis. Female and young people received high protection from vitamin D in melanoma. XGBoost can accurately prediction the possibility of melanoma based on vitamin D.