AUTHOR=Yang Fan , Fu Haixiao , Zheng Xiang , Yang Yuzhong , Zhou Quyan , Liang Yuanna , Zheng Jinhua , Lin Jing 

TITLE=SMARCA4-deficient undifferentiated carcinoma co-existing with primary endometrial gastric (or gastrointestinal) -type carcinoma: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1510930

DOI=10.3389/fonc.2025.1510930

ISSN=2234-943X

ABSTRACT=Dedifferentiated endometrial carcinoma (DEC) is a rare and highly malignant endometrial tumor consisting of both undifferentiated endometrial carcinoma (UEC) and differentiated components (that are typically grade 1 or 2 endometrioid carcinomas). By contrast, the coexistence of UEC with a high-grade endometrial carcinoma has not been well reported. Primary endometrial gastric (gastrointestinal)-type carcinoma (PEGT-carcinoma) is a newly classified and rare type of female genital tract cancer, this neoplasm belongs to high-grade endometrial carcinoma and tends to have a poor outcome. In this study, we reported an atypical case of DEC composed of SMARCA4-deficient UEC and PEGT-carcinoma and reviewed its clinicopathological features.