AUTHOR=Shi Mingrui , Han Ming , Wang Jiale , Zhao Qi , Ren Chenghao , Li Huan , Yang Zihui , Wei Jianhua , Yang Xinjie 

TITLE=Glomus tumor of the hyoid bone: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1512465

DOI=10.3389/fonc.2025.1512465

ISSN=2234-943X

ABSTRACT=Hyoid glomus tumors represent an exceptionally rare clinical entity. This study details a case presentation of a hyoid glomus tumor accompanied by a comprehensive systematic review, aiming to expand the clinical and pathological understanding of these uncommon neoplasms while evaluating therapeutic approaches. CT imaging revealed hyoid bone destruction with features suggestive of a borderline neoplasm. Histopathological examination demonstrated local spindle-shaped cells exhibiting a chicken claw-like morphology, which showed strong immunoreactivity for SMA, calponin, and collagen type IV - findings consistent with classical glomus tumor characteristics. The patient was ultimately diagnosed with a glomus tumor of uncertain malignant potential. Postoperative recovery proceeded favorably, with serial follow-up imaging studies demonstrating no evidence of recurrence or residual disease over several months of surveillance.