AUTHOR=Li XiangHua , Wang DongFei , Yin DeTao 

TITLE=Clinical characteristics and recurrence predictors of sinonasal inverted papilloma: a retrospective cohort study

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1537905

DOI=10.3389/fonc.2025.1537905

ISSN=2234-943X

ABSTRACT=ObjectiveTo investigate the clinical characteristics and predictors of postoperative recurrence in sinonasal inverted papilloma (SNIP).MethodsA retrospective cohort study of 53 SNIP patients treated at Zhengzhou University Hospital (2019–2023) was conducted. Patients were stratified into primary (n=34) and recurrent (n=19) cohorts. Clinical variables were analyzed using univariate and multivariate logistic regression.ResultsSmoking (OR=10.08, 95% CI=1.32–77.15), prior surgery (OR=17.26, 95% CI=2.69–110.76), and ipsilateral involvement (OR=7.79, 95% CI=1.05–57.99) emerged as independent recurrence predictors (P<0.05). Krouse staging (T3 vs. T1–T2) showed no significant association (P=0.198).ConclusionComprehensive evaluation of smoking history, surgical history, and lesion laterality is critical for recurrence risk stratification in SNIP management.