AUTHOR=Zhang Ziyi , Pang Wenhui , Chen Min , Jiang Yan , Zhao Yuhui , Fu Shengyao , Wen Junfeng 

TITLE=Case Report: Two cases of atypical neurofibroma neoplasm of uncertain biological potential in the nasal cavity and a literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1539671

DOI=10.3389/fonc.2025.1539671

ISSN=2234-943X

ABSTRACT=ObjectiveThis study aims to investigate the clinical diagnosis, treatment processes, and pathological characteristics of two cases of atypical neurofibroma neoplasm of uncertain biological potential (ANNUBP) located in the nasal cavity.Materials and MethodsWe retrospectively analyzed the medical history, imaging studies, pathological results, and follow-up data of two patients diagnosed with nasal ANNUBP who were admitted to Qingdao University Hospital between June and October 2023. A review of relevant literature was conducted to summarize their clinical characteristics, diagnosis, treatment, and prognosis.ResultsBoth patients underwent surgical treatment, with one receiving postoperative radiotherapy. Follow-up evaluations indicated that both patients experienced satisfactory recovery, with no signs of local recurrence or distant metastasis.ConclusionANNUBP is a recently recognized and rare subtype of neurogenic tumor. Surgical intervention is regarded as an effective treatment method. This study adhered to established treatment principles for nasal tumors and achieved satisfactory outcomes through surgical intervention and diligent postoperative follow-up.