AUTHOR=Xu Zichao , Wang Minjie , Gong Long , Luo Guanghong , Zhang Yucong , Zhou Yayan , Li Zihuang 

TITLE=Promising outcomes of the PD-L1 inhibitor Socazolimab in recurrent and metastatic cervical cancer: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1541760

DOI=10.3389/fonc.2025.1541760

ISSN=2234-943X

ABSTRACT=Recurrent and metastatic advanced cervical cancer carries a poor prognosis, and there is currently no standardized treatment regimen. Immunotherapy, as an emerging and effective treatment strategy, has attracted significant attention. Socazolimab, a programmed death ligand 1 monoclonal antibody developed in China, is primarily used to treat patients with recurrent or metastatic cervical cancer who have failed or are intolerant to first-line platinum-based chemotherapy, regardless of programmed death ligand 1 expression status. We report the case of a Chinese patient with advanced cervical cancer and multiple metastases, who showed significant tumor regression after receiving Socazolimab treatment. Currently, during ongoing immunotherapy, the tumor continues to demonstrate persistent remission, with no new lesions observed. This case suggests that Socazolimab may offer a promising therapeutic option for patients with metastatic cervical cancer. In this report, the safety profile of Socazolimab was favorable, with no severe or uncontrollable adverse events. This case provides compelling evidence of the antitumor activity and manageable toxicity of Socazolimab in metastatic cervical cancer patients, offering valuable insights for further research and clinical application of the drug.