AUTHOR=Zhang Donghuan , Lin Lanlan , Jin Hui , Mao Huajun , Wang Luying , Ma Wenwen , Lao Zhenghong 

TITLE=Endoplasmic reticulum stress in lung cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1550075

DOI=10.3389/fonc.2025.1550075

ISSN=2234-943X

ABSTRACT=Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion. Multiple factors in the tumor microenvironment may induce the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum and trigger endoplasmic reticulum (ER) stress. Adaptive mechanisms including unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) are activated in response to ER stress. Previous studies have revealed that ER stress may participate in epithelial mesenchymal transformation, apoptosis, metabolic regulation and drug resistance of lung cancer cells. Herein, we summarized the potential effects and regulatory mechanisms of ER stress on the biological process of lung cancer, which may provide scientific significance and clinical value for elucidating the adaptability of lung cancer cells under stress and developing novel targeted therapies.