AUTHOR=Abu Taha Shatha , Abu Hejleh Taher , ElHaddad Mostafa , Al-Ibraheem Akram , Abbasi Ahmed , Sumaida Abdulrahman , Bushehri Ahmad , Mostafa Ahmad , Youssef Bassem , Alotain Ibrahim , Abu-Gheida Ibrahim , Aldehaim Mohammed , Alghamdi Majed , Shelan Mohamed , Al Dohan Mohammed , Al-Hussaini Maysa , Pervez Nadeem , Temraz Shoukri , Alrashidi Saad , El-Sheshtawy Wael , Al-Mandhari Zahid , Ghatasheh Hamza , Hosni Ali , Mohamad Issa TITLE=Chemotherapy-free innovations in locally advanced head and neck cancer: a comprehensive review JOURNAL=Frontiers in Oncology VOLUME=Volume 15 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1552337 DOI=10.3389/fonc.2025.1552337 ISSN=2234-943X