AUTHOR=Xu Ziye , Xu Manbin , Sun Zhichen , Feng Qin , Xu Shaowei , Peng Hanwei 

TITLE=A nomogram for predicting overall survival in oral squamous cell carcinoma: a SEER database and external validation study

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1557459

DOI=10.3389/fonc.2025.1557459

ISSN=2234-943X

ABSTRACT=PurposeOral squamous cell carcinoma (OSCC) often presents with unsatisfactory survival outcomes, especially in advanced stages. This study aimed to develop and validate a nomogram incorporating demographic, clinicopathologic, and treatment-related factors to improve the prediction of overall survival (OS) in OSCC patients.MethodsData from 15,204 OSCC patients in a US database were retrospectively utilized to construct a prognostic model and generate a nomogram. External validation was performed using an independent cohort of 359 patients from a specialized cancer center in China. Prognostic factors were identified using Cox regression analysis and incorporated into the nomogram. Model performance was evaluated by concordance index (C-index), time-dependent area under the receiver operating characteristic curves (AUC), calibration plots, and decision curve analysis (DCA). A risk stratification system was developed to classify patients into high- and low-risk groups.ResultsAge, sex, primary tumor site, T and N staging, and treatment modalities (including surgery, chemotherapy, and radiotherapy) were found to be independent prognostic factors. The nomogram achieved a C-index of 0.727 in the training set and 0.6845 in the validation set, outperforming the conventional TNM staging system. The nomogram’s superior predictive accuracy was confirmed by higher AUC values, better calibration, and improved clinical utility as demonstrated by DCA. Risk stratification, based on the nomogram, distinguished patients into distinct prognostic groups with significant OS differences.ConclusionsThis nomogram provides an effective, personalized tool for predicting OS in OSCC. It offers clinicians a valuable aid for treatment decision-making and improves patient management.