AUTHOR=Li Yanru , Teng Lukang , Wang Shupeng , Wu Xudong , Huang Tianchen 

TITLE=Rare comorbidity of colon cancer, hepatic malignant mesothelioma, and abdominal Ewing’s sarcoma: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1558347

DOI=10.3389/fonc.2025.1558347

ISSN=2234-943X

ABSTRACT=We present a rare case of a patient with a history of colon cancer who subsequently developed hepatic mesothelioma and extraosseous Ewing’s sarcoma 10 years after surgery. The diagnosis of three completely different types of cancer in the same patient over a decade was confirmed through histopathological and immunohistochemical analysis. This case highlights the importance of clinicians maintaining a heightened awareness and clinical vigilance regarding multiple primary cancers, ensuring patients receive comprehensive diagnosis and treatment for improved prognosis and desired survival outcomes.