AUTHOR=Sun Ting-Ting , Sun Xue-Guo , Shan Ti-Dong , Zhao Peng , Lu Yan-Yan , Li Qian , Liu Fu-Guo 

TITLE=Castleman disease of stomach treated by endoscopic submucosal dissection: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1563545

DOI=10.3389/fonc.2025.1563545

ISSN=2234-943X

ABSTRACT=BackgroundCastleman disease (CD) is a relatively rare benign lymphoproliferative disorder of the lymphoid tissue. According to clinical manifestations, it is classified into two types: unicentric CD (UCD) and multicentric CD (MCD). Pathological subtypes include hyaline-vascular (HV), plasma cell (PC), and mixed (MV). Gastrointestinal CD is extremely rare, and limited information is available regarding its clinical presentation and management.Case SummaryWe report a case of a patient who presented with paroxysmal epigastric pain for 4 years. Laboratory tests showed no remarkable abnormalities, whereas CT revealed endogenous occupancy on the side of the greater curvature of the stomach. Ultrasonographic endoscopy demonstrated hypoechoic, well-defined foci. The lesion initially suspected to be an inflammatory fibroma was subsequently pathologically confirmed as HV-UCD following endoscopic submucosal dissection. The lesion was completely resected, and the patient showed no signs of recurrence during 7 months of follow-up.ConclusionGastrointestinal CD is rare and should be differentiated from other occupying lesions. Its definitive diagnosis relies on histopathology.