AUTHOR=Zheng Siming , Sagar A. S. M. Sharifuzzaman , Chen Yu , Yu Zehao , Ying Shi , Zeng Yongyi 

TITLE=DynTransNet: Dynamic Transformer Network with multi-scale attention for liver cancer segmentation

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1569083

DOI=10.3389/fonc.2025.1569083

ISSN=2234-943X

ABSTRACT=IntroductionHepatocellular carcinoma (HCC), a predominant subtype of liver cancer, remains Q7 a major contributor to global cancer mortality. Accurate delineation of liver tumors in CT and MRI scans is critical for treatment planning and clinical decision-making. However, manual segmentation is time-consuming, errorprone, and inconsistent, necessitating reliable automated approaches.MethodsThis study presents a novel U-shaped segmentation framework inspired by U-Net, designed to enhance accuracy and robustness. The encoder incorporates Dynamic Multi-Head Self-Attention (D-MSA) to capture both global and local spatial dependencies, while the decoder uses skip connections to preserve spatial detail. Additionally, a Feature Mix Module (FM-M) blends multiscale features, and a Residual Module (RM) refines feature representations and stabilizes training. The proposed framework addresses key challenges such as boundary precision, complex structural relationships, and dataset imbalance.ResultsExperimental results demonstrate superior segmentation performance, achieving a mean Dice score of 86.12 on the ATLAS dataset and 93.12 on the LiTS dataset.DiscussionThe proposed method offers a robust, efficient tool for liver tumor segmentation and holds strong potential to streamline diagnostic workflows and improve automated medical image analysis in clinical practice.