AUTHOR=Padurariu-Covit Monica-Daniela , Chiscop Iulia , Gutu Cristian , Arbune Anca-Adriana , Niculet Elena , Arbune Manuela 

TITLE=Retrospective analysis of HIV-associated lymphomas: insights from a single Romanian center over 15 years

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1569433

DOI=10.3389/fonc.2025.1569433

ISSN=2234-943X

ABSTRACT=IntroductionLymphoma is a significant cause of mortality among people living with human immunodeficiency virus (PLWH). The objective of our study was to assess the characteristics of lymphomas in PLWH in a single center from the southeast of Romania.MethodsWe retrospectively analyzed the prevalence and clinical and demographic characteristics of patients with lymphoma associated with HIV/AIDS monitored over a period of 15 years. Kaplan–Meier analysis was used to estimate survival rates and evaluate the risk of mortality in lymphoma patients.ResultsAmong the 476 new cases of HIV/AIDS registered, 9 cases of lymphoma were identified, representing a prevalence of 1.89%. Overall mortality was 13.6%, with lymphoma contributing to 10.76% of HIV/AIDS-related deaths. The average age at lymphoma diagnosis was 37 years, with most patients being men and smokers with sexually transmitted HIV. Common coinfections included hepatitis B virus (HBV) and tuberculosis. Advanced-stage disease (Ann Arbor stage IV) and type B clinical symptoms were present in half of the cases. Oncological treatment was provided in 5 cases, achieving a survival rate of 30%.ConclusionsThe high mortality highlights the need for early diagnosis and an integrated therapeutic approach to improve the prognosis of patients with HIV-associated lymphomas.